ch 11 pt 4 Flashcards
leukocytes (wbc) are produced in ___ stem cells
marrow
increased wbc is termed ___ while decreased wbc is called ___
leukocytosis
leukopenia
neutrophils (MC), eosinophils and basophils are all types of _____
granulocytes
monocytes and lymphocytes (t, b, nk cells) are types of ___
agranulocytes
wbc d/o can be ___, to underlying disease like a microbial infx (mc) or more ominously are ____ and contrib 9% of adult ca death 40% childhood ca death
reactive
neoplastic
decreased granulocytes (neutrophils), as seen in HIV or prolonged corticosteroid use is termed
neutropenia
__ __ failure can occur from mets, infx, AI injury, granulomas, adr’s chemo
____ poses an infxn risk either bact or fungal
bone marrow
neutropenia
mono is caused by an infection of ____ and can cause reactive lymphocytosis, in which infected b cells become ____ ____
EBV
atypical lymphocytes
dx for the EBV antibodies seen in mono
monospot test
- in developing countries, mono infx occurs in ___ and is mc _____
- in developed countries it occurs in ___ and is mc ____
childhood/asymptomatic
adolescence/symptomatic
cat scratch disease is caused by the bact infx from __ __, occurs 2 wk after the scratch, but lasts 2-4 months
bartonella henselae
non hodgkin lymphomas, hodgkin lymphoma, plasma cell neoplasia are all types of ___ neoplasms of wbc
lymphoid
acute myelogenous leukemia, myelodysplastic syndromes, chronic myeloproliferative d/o are all types of ___ neoplasms of wbc
myeloid
macrophages and dendritic cells are involved in ___ neoplasms of wbc
histiocytic
with lymphoid neoplasms, ___ involves marrow or blood, while ___ involves lymphatic tissues
leukemia
lymphoma
ACUTE leukemia involves ___ suppression, mc anemia (fatigue), and is dx via biopsy detection of ___, which become aggressive tumors
marrow
lymphoblasts
acute lymphoblastic leukemia (ALL) characteristically involves both:
pre-B cells (tumors MC here)
pre-T cells
pre-b cell tumors are mc in the ____ and periph blood, while pre-t cell tumors occur in the ___
marrow
thymus
mc demographic for ALL, and mc dx age
children
age 4
___, the decrease of all circulating blood cells, occurs with ALL, and the treatment is chemo
-80% cured ages 2-10 yo
pancytopenia
MC leukemia of adulthood mc dx at age 60, involves B cells
CLL (chronic lymphocytic leukemia)
indolent, initially asymp, with a gradual progression, CLL requires a count of ____ lymphocytes/uL involving BLOOD
-MC than SLL
> 4000
“CLL” is considered SLL (small lymphocytic lymphoma) is there are ____ lymphocytes/uL, involving NODES
in CLL, tumor cells displace marrow and cause ____
pancytopenia
in CLL there is immune dysregulation due to suppressed ____, as well as _______ which is decreased antibodies/globulins in circulation
B cells
hypogammaglobulinemia
median survival post-prognosis of CLL
4-6 years
if CLL transitions into the extremely aggressive form, it resembles ______, which then has around a 1 year survival rate
diffuse large b cell lymphoma
