ch 11 pt 4

Question 1

leukocytes (wbc) are produced in ___ stem cells

Answer 1

marrow

Question 2

increased wbc is termed ___ while decreased wbc is called ___

Answer 2

leukocytosis

leukopenia

Question 3

neutrophils (MC), eosinophils and basophils are all types of _____

Answer 3

granulocytes

Question 4

monocytes and lymphocytes (t, b, nk cells) are types of ___

Answer 4

agranulocytes

Question 5

wbc d/o can be ___, to underlying disease like a microbial infx (mc) or more ominously are ____ and contrib 9% of adult ca death 40% childhood ca death

Answer 5

reactive

neoplastic

Question 6

decreased granulocytes (neutrophils), as seen in HIV or prolonged corticosteroid use is termed

Answer 6

neutropenia

Question 7

__ __ failure can occur from mets, infx, AI injury, granulomas, adr’s chemo
____ poses an infxn risk either bact or fungal

Answer 7

bone marrow

neutropenia

Question 8

mono is caused by an infection of ____ and can cause reactive lymphocytosis, in which infected b cells become ____ ____

Answer 8

EBV

atypical lymphocytes

Question 9

dx for the EBV antibodies seen in mono

Answer 9

monospot test

Question 10

• in developing countries, mono infx occurs in ___ and is mc _____
• in developed countries it occurs in ___ and is mc ____

Answer 10

childhood/asymptomatic

adolescence/symptomatic

Question 11

cat scratch disease is caused by the bact infx from __ __, occurs 2 wk after the scratch, but lasts 2-4 months

Answer 11

bartonella henselae

Question 12

non hodgkin lymphomas, hodgkin lymphoma, plasma cell neoplasia are all types of ___ neoplasms of wbc

Answer 12

lymphoid

Question 13

acute myelogenous leukemia, myelodysplastic syndromes, chronic myeloproliferative d/o are all types of ___ neoplasms of wbc

Answer 13

myeloid

Question 14

macrophages and dendritic cells are involved in ___ neoplasms of wbc

Answer 14

histiocytic

Question 15

with lymphoid neoplasms, ___ involves marrow or blood, while ___ involves lymphatic tissues

Answer 15

leukemia

lymphoma

Question 16

ACUTE leukemia involves ___ suppression, mc anemia (fatigue), and is dx via biopsy detection of ___, which become aggressive tumors

Answer 16

marrow

lymphoblasts

Question 17

acute lymphoblastic leukemia (ALL) characteristically involves both:

Answer 17

pre-B cells (tumors MC here)

pre-T cells

Question 18

pre-b cell tumors are mc in the ____ and periph blood, while pre-t cell tumors occur in the ___

Answer 18

marrow

thymus

Question 19

mc demographic for ALL, and mc dx age

Answer 19

children

age 4

Question 20

___, the decrease of all circulating blood cells, occurs with ALL, and the treatment is chemo
-80% cured ages 2-10 yo

Answer 20

pancytopenia

Question 21

MC leukemia of adulthood mc dx at age 60, involves B cells

Answer 21

CLL (chronic lymphocytic leukemia)

Question 22

indolent, initially asymp, with a gradual progression, CLL requires a count of ____ lymphocytes/uL involving BLOOD
-MC than SLL

Answer 22

> 4000

Question 23

“CLL” is considered SLL (small lymphocytic lymphoma) is there are ____ lymphocytes/uL, involving NODES

Question 24

in CLL, tumor cells displace marrow and cause ____

Answer 24

pancytopenia

Question 25

in CLL there is immune dysregulation due to suppressed ____, as well as _______ which is decreased antibodies/globulins in circulation

Answer 25

B cells

hypogammaglobulinemia

Question 26

median survival post-prognosis of CLL

Answer 26

4-6 years

Question 27

if CLL transitions into the extremely aggressive form, it resembles ______, which then has around a 1 year survival rate

Answer 27

diffuse large b cell lymphoma