ch 18 pt 1 Flashcards
___ of the vulva is mc and ___ is rare
inflammation
neoplasia
inflam of vulva that has many causes including allergic contact dermatitis (eczema), skin infx or a bartholin’s cyst which can obstruct a duct
vulvitis
epi thinning that causes white lesion near labia minora from an idiopathic cause, mc thought to be autoimmune
lichen sclerosis
mc demographic for lichen sclerosus, which has a small (1-5% SCC) ca risk
elderly
epi hyperplasia and hyperkeratosis from chronic irritation, shows with leukocytes and NO CA RISK
lichen simplex chronicus
though both resemble leukoplakia, lichen sclerosis has ___ epi while lichen simplex chronicus has ___ epi
- LS has MIN dermal inflam
- LSC has dermal inflam + leukocytes
thinned
thickened
- condylomata ____ is a secondary syph infection with flat, moist, painless warty lesions
- condylomata ____ is genital warts (HPV6,11)
lata
acuminata
vulvar carcinoma is rare, mc in those >60 yo, but ___% is SCC
90
HPV-related SCC follows vulvar ___ ___ (VIN), a pre-ca lesion or HPV __ and ___ (both high risk)
intraepithelial neoplasia
16 and 18
non HPV related SCC is MC and is seen in older women, and follows ___ ____, no VIN
lichen sclerosis
common, benign and transient inflam of vagina that may present with leukorrhea, pain, pruritis
-bact or fungi infx
vaginitis
vaginal SCC is rare but is mc in those > __ yo, and in pt with ___
60
HPV
type of rare vaginal CA with red/granular foci that is a result from an ADR in mothers who took DIETHYLSTILBESTROL (DES)
clear cell adenocarcinoma
type of embryonal rhabdomyosarcoma mc seen in pt less that 5 yo
sarcoma botryoides
___ is common and benign and possibly asymptomatic though may present with leukorrhea, pain, bleeding - and should prompt pelvic exam
cervicitis
MC cause of infectious cervitis
chlamydia trachomatis
high risk HPV (2), that have a 70% of evolving into ca, esp in the TRANSFORMATION ZONE
16
18
most HPV inx are ___ for months, only a few persist into cervical intraepi neoplasia (CIN)
transient
the _____ zone is within the cervix and everts during puberty when columnar cells undergo squamous metaplasia
transformation
neoplasia of cervix from HPV to dysplasia (pre-ca lesion) that is MC dx at 30 yo
-is usually asymptomatic
CIN
- ____ (CIN I) req only observation as 60% regress and 10% progress to next stage
- ____ (CIN II-III) req excision as only 30% regress and 10% prog into CA
low grade
high grade
- progressive change from normal to cancerous cells in CIN
- enlarged nucleus, anaplasia, irreg borders, dark
koilocytosis
biopsy for CIN following an abnormal pap smear
colposcopy
invasive carcinoma of the cervix (ICC) is ___% mc SCC, and is MC dx in mid ___
75%
40s
with a cervical lesion less than 3mm, the chance of mets is __%, but with a lesion greater than 3mm the chance is __%
1
10
early on ICC is asymptomatic but can cause local invasion and is commonly lethal due to obstruction and renal failure, which is why this population of women is at risk:
w/o previous/yearly pap smear
inflam of endometrium that is MC secondary to pelvic inflam disease or also from retained products internally
endometritis
- extrauterine endometrial tissue including ovaries, peritoneum, pouch of douglas, uterine ligs, fallopian tubes, nodes, heart, lungs, etc
- causes cyclic bleeding and fibrosis
endometriosis
characteristic of endometriosis
chocolate cyst
___ is profuse/prolonged menstruation while _____ is irregular spotting bt periods
MENOrrhagia
METROrrhagia
