ch 11 pt 5

Question 1

___ lymphoma involves b cells and is named for the pattern on the cells

Answer 1

follicular

Question 2

lymphocytes with abnormal, cleaved nuclei that are involved in follicular lymphoma

Answer 2

centrocytes

Question 3

follicular lymphoma features generalized lymphadenopathy and is characteristically painless, MC onset is > ___

Answer 3

50 yo

Question 4

follicular lymphoma has a variable prognosis of 1-20 years (7-9 on ave), but is ____

Answer 4

incurable

Question 5

____ lymphoma involves b cells, is mc dx >50 yo, is aggressive/poor prognosis and is incurable as it is MC dx in advanced stage

Answer 5

mantle cell

Question 6

mc lymphoma of adulthood involving large B cells (3-4x size), is ave dx at 60 yo

• previous EBV incr risk
• rapidly fatal

Answer 6

diffuse large b cell lymphoma

Question 7

diffuse large b cell lymphoma commonly presents outside the nodes, such as in the ____ but with aggressive chemo 80% will remit, 50% cured

Answer 7

GI tract

Question 8

___ lymphoma involves b cells and MC affects children, esp the facial structures (max/mand) and in african american

Answer 8

burkitt

Question 9

lymphoma that creates a histological “starry sky” pattern as b cell areas erode away
-one of fastest growing human neoplasms

Answer 9

burkitt

Question 10

burkitt lymphoma has a good prognosis if tx with:

Answer 10

aggressive chemo

Question 11

MC (MALIGNANT) plasma cell ca, dx around 70 years and has characteristic punched out osteolytic lesions in skull/bone
-incurable

Answer 11

multiple myeloma

Question 12

renal failure can occur in multiple myeloma, and is viewed histologically via:

Answer 12

bence-jones proteins

Question 13

multiple myeloma is dx via bence jones proteins or via a ____ on protein electrophoresis

Answer 13

m spike

Question 14

top 3 locations of lytic lesions of multiple myeloma

Answer 14

vertebral column
ribs
skull (calvarium)

Question 15

hallmark feature of hodgkin lymphoma (HL), along with arising from a single node with predictable mets to nearby nodes

Answer 15

reed-sternberg cell (owl eye)

Question 16

HL is similar to follicular lymphoma in that it has painless ______, but instead infects a ___ node instead of systemic infection like follicular

Answer 16

lymphadenopathy

single

Question 17

HL presents with night sweats, and the etiology is idiopathic but a previous EBV infx increases the risk 70%, mc demographics for HL are:

Answer 17

males
15-40
>55

Question 18

___ neoplasms MC affect adults, and are named for the precursor myeloblast involvement giving rise to other cells

Answer 18

myeloid

Question 19

aggressive poor prognosis leukemia that is avg dx around 50 yo and involves immature myeloblasts that displace >20% of bone marrow and cause marrow failure

Answer 19

acute myeloid leukemia (AML)

Question 20

acute myeloid leukemia features pancytopenia and has a worse prognosis with a history of:

Answer 20

myelodysplastic syndromes

Question 21

“pre-leukemia” mc dx 50-70 where marrow fills with myeloblasts, 40% transform into AML, pancytopenia with a survival 1-2 yr

Answer 21

myelodysplastic syndromes

Question 22

GROUP of indolent tumors, hyperplastic myeloid progenitors that retain ability to differentiate but create amt of disporoportionate rbcs
-MC adults 30-50 yo

Answer 22

chronic myeloproliferative d/o

Question 23

chronic myeloproliferative d/o can spread to other organs and is slowly progressive, potentially causing extreme ___

Answer 23

splenomegaly

Question 24

____ occurs with chronic myelogenous leukemia, with >100,000 types of cells/uL, MC granulocytes and megakaryocytes

Answer 24

leukocytosis

Question 25

pt with chronic myelogenous leukemia 95% of the time have the presence of a ____ chromosome, which causes the translocation of ____

Answer 25

philadelphia (Ph)

t(9;22)

Question 26

if chronic myelogenous leukemia transitions into a ____ phase, it resembles ALLL, has a poor prognosis of only about 3 yr

Answer 26

spent

Question 27

myeloid neoplasm with panmyelosis, but too many RBCs is most concerning
-dx over 60 yo

Answer 27

polycythemia vera (PCV)

Question 28

PCV has a point mutation on ____, and involves DECREASED EPO

Answer 28

JAK2

Question 29

PCV causes multiple organ congestion, pruritis, dysfunctional platelets that uniquely _____

Answer 29

hemorrhage

Question 30

PCV has a prognosis WITH treatment of __-__ post dx, but without tx it is only ___

Answer 30

10-20

3

Question 31

myeloid neoplasm with an early spent phase of diffuse marrow fibrosis that leads into hematopoiesis to extramedullary sites, causing massive splenomegaly
-poor prog due to late stage dx

Answer 31

primary myelofibrosis