Cell to cell communication Flashcards
Categories of chemical signaling (4)
Free diffusion: adjacent or distant
Cell signal to itself
Cell to cell contact
The adjacent cell communication is in
With the interstitial space
Extracellular signaling can (5)
- Coordinate the aggregation of movement of cells
- Initiate control under certain environmental conditions
- alter gene expression
- control metabolic processes between cells
- Contribute to nerve conduction
What metabolic processes can the extracellular signaling control (2)
Synthesis and secretion of proteins
Composition of intracellular and extracellular fluid
Types of signal molecules (4)
Small lipophilic molecules
Small hydrophobic molecules from a.a.
Gases
Physical stimuli (light)
What is a ligand
A signaling molecule
What does reception mean
Molecule to molecule contact
The target cell action depends on (4)
Signals that are present
Receptors that the target cell expresses on surface or IC
Signaling cascades
IC targets
What does ligand do
Bind together
What is a ligand
Molecule that binds to specific molecule called receptor
What is needed in order to detect a signal
The receiving cell must have the right receptor for that signal
What happens when a signaling molecule binds to a receptor
Alters the shape and activity of the receptor causing a change in the cell
T or F
A specific ligand with have a specific receptor that can bind to other ligands
False
Receptors are specific for one ligand
Types of ligands (2)
Those that enter the cell
Those that bind to receptors outside of cell
Properties of ligands(3)
Hydrophobic
Lipophilic
Can pass through membrane and bind to IC receptros in the nucleus or cytoplams
What type of ligand can directly travel across the membrane due to its small size
Nitric oxide (NO)
What is the key role of nitric acid as a ligand
Activate a signaling pathway in the smooth muscle surrounding blood vessels
Can make a muscle relax and blood vessels expand (dilate)
Properties of water soluble ligands (3)
Polar or charged
Cannot pass or cross the PM
Bind to extracellular domains of cell surface receptors staying on the outer surface
Example of water soluble ligand
Peptide protein ligands such as insulin and certain neurotransmitters
Different types of neurotransmitters (4)
Some are peptides
Other small hydrophilic organic molecules
Standard a.a.
Modified or non standard
What peptides are neurotransmitters(2)
Oxytocin
Endorphin
What types of hydrophilic molecules are neurotransmitters
Monoamines such as dopamine
What standard a.a. are neurotransmitters (2)
Glutamate and glycine
Examples of ligand (6)
Steroid hormones Growth factors and hormones Neurotransmitters Nitric oxide Light or photo transduction Pressure or mechanotransducyion
Types of receptors (2)
Internal
Cell surface receptors
Internal receptors are where
IC and in the cytoplasm of the cell
Internal receptors respond to what type of ligand
Hydrophobic ligand that can travel across the PM
Ligand-binding causes
A conformational change that exposes the DNA binding site on protein
What causes the initiation of transcription and gene expression in a cell
When the ligand receptor complex moves into the nucleus and binds into a specific regulatory region of chromosomal DNA
T or F
With the internal receptors after the ligand has binded to the receptor and moved in the nucleus, you need other types of receptors and signals.
False
No need
What are the cell surface receptors
Membrane anchored (integral) proteins that bind external ligand molecules
What are the cell surface receptors also called
Transmembrane receptors
What do the cell surface receptor do to the PM
Spans it and produce a signal transduction in which EC signal is converted into IC signal
Main components of the cell surface receptors (3)
External ligand binding domain
Hydrophobic membrane spanning region
IC domain inside cell
Autocrine signals are produced by
What does that mean
Signaling cells that can also bind to the ligand that is released
Meaning that signaling cells and target cells can be the same or similar
Autocrine signaling can (2)
Regulate inflammation and pain responses
Signal apoptosis when the cell is infected by a virus
T or F
Abnormal autocrine signaling contributes to uncontrolled growth of cells such as cancer cells
True
Endocrine signaling are
Signals from distant cells originated from endocrine cells
T or F
Endocrine signals can produce faster responses but have a short lasting effect
False
Slower response
Long lasting effect
Ligands released from the endocrine signals are called
Hormones
What are hormones
Signaling molecules that are produced in one part of the cell but affect other body regions
How can hormones travel to target cells
Through the blood stream
What happens to the hormones when they act on target cells
They get diluted and are present in low concentrations
Paracrine signaling examples
Synaptic signaling
What is synaptic signaling (2)
Nerve cells transmit signal
Process named for the synapse, the junction between two nerve cells where signal transmission occurs
Types of cell to cell connections (4)
Tight junctions
Adherence junctions
Desmosomes
Gap junctions
Tight junctions
Seal the adjacent epithelial cells in a narrow band
Where can i find a tight junction
In lung epithelium
Adherence junctions
Provide strong mechanical attachments between adjacent cells
Where can i see adherence junctions
Cardiac muscle
Desmosomes
Hold a cell tightly together by linking IC to the intermediate filament cytoskeleton
Gap junctions
Allow signaling between cells
How do animal cells connect between PM and neighboring cells
Gap junctions
In plants what is the connection between plasma M and other cells
Plasmodesmata
Stages of signaling (3)
Ligand binding
Transduction
Cellular response
What happens in transduction
Amplification and spreading across specific pathway
What happens in cellular response (4)
Gene transcription
Cell proliferation
Differentiation
Cell survival
T or F
Ligands cannot act in 2 or 3 of the cell to cell signaling
False they can
Example of a ligand acting in more than one cell signaling
Epinephrine
Acts as a neurotransmitter and systemic hormone
So paracrine and endocrine signaling
What protein hormone is synthesized as the exoplasmic part of plasma membrane protein that can bind and signal an adjacent cell by direct contact
Epidermal growth factor
T or F
Ligands exhibit versatility just like receptors
FALSE
Ligands show versatility for receptors but the receptor displays high specificity to that ligand
Meaning a ligand can bind to many receptors while the receptor can only bind to a specific ligand
T or F
The response to a chemical signal decreases when EC concentrations of signals increase
False
Increase when EC concentrations increase
The more EC ligands means
The more responses
Maximum cellular response happens when
Saturation is reached due to finite numbers of receptors
T or F
Chemical signals don’t need to compete for a receptor
False
If they have similar structures they will and can compete for the same receptor
Can the same receptor trigger a different response in a ligand
Yes
An example of a receptor that can have different effects on a ligand
Explain
Acetylcholine
Release from a neuron adjacent to a striated muscle will trigger contraction where as if it was adjacent to the heart muscle it will slow down the rate of concentration
Where is acetylcholine found
On surface of striated muscle cells, hear muscles, and pancreatic acinar cells
Effects of acetylcholine in pancreatic acinar cells
Triggers exocytosis of secretory granules that contain digestive enzymes
T or F
Different ligand-receptor complexes can induce the same cellular response in some cell types
True
Example of specific mediated responses from different hormone-ligand complexes
Activation of epinephrine and glucagon receptors in liver cells by binding to their respective ligands induces synthesis of cAMP (2nd messenger)
So effect is identical in liver
T or F
Ligands can be metabolized for other products, is an intermediate in cellular activity and has important enzymatic activity
False
I doesn’t do anything
What is the function of the ligand
Bind to the receptor
Classes of cell surface receptors (4)
G protein coupled receptors
Ion channel receptors
Tyrosine-kinase linked receptors
Receptors with intrinsic enzymatic activity
Examples of G protein CR (3)
Epinephrine
glucagon
Serotonin
Examples of ion channel receptors
Acetylcholine
Example of Tyrosine-kinase linked receptor (2)
Erythropoietin
Interferon
The name of classes of receptors refer to
The mechanism by which the receptors transform EC signals into IC ones
T or F
Cell surface receptors can make changes in the function of the cell without actually going inside the cell
Explain
True
Because they work/ interact with EC and IC signals
Ion channels receptors are also called
Ligand gated ion channel receptors
The conformational changed caused by ligand binding in the receptor (ion channel receptor)allows what type of ions to pass through (5)
Ca K Na Mg H
What ligands work mostly with ion channel receptors (2)
Neurotransmitter such as glutamate
Acetylcholine
Example of receptors with intrinsic enzymatic activity
Explain
Atrial naturetic protein
Binds to its receptor causing a reduction in blood volume
So a decreased in cardiac output and systemic blood pressure occurs
Lipolisis increases and renal sodium decrease
The overall effect is to counter increase in blood pressure and volume caused by the renin angiotensin system
Enzyme linked receptors lack
Lack intrinsic catalytic activity but ligand binding stimulates formation of a dimeric receptor
What happens to the dimeric receptor formed by the ligand bonding in enzyme linked receptors
Interacts and activates cytosolic protein-tyrosine kinases
When the ligand binds, it activates a signal transduction cascade, what is the first thing released from this
G protein coupled receptors
The activation of an enzyme by a G protein generates what
A specific 2nd messenger or modulates ion channel, changing the membrane potential