Cell Junctions Flashcards
Direct attach between cells are made by
Cell-cell junctions
Cell junctions are more abundant in (5)
Epithelial tissue Connective tissue Cardiac muscle Smooth muscle Nervous tissue
What types of junctions are in cell to cell junctions (3)
Tight junctions
Cell-cell anchoring junctions
Gap junctions
What types of junctions are in cell to matrix junctions
Cell matrix anchoring junctions
What are the cell to cell anchoring junctions (2)
Adherens junctions
Desmosome
What are in the cell to matrix anchoring junctions
Actin linked cell matrix junctions
Hemidesmosome
Tight junctions are (3)
Seal gap between epithelial cells
Most apical location
Found in epithelial cells
Where are tight junctions found
Epithelial cells
In lining intestinal mucous
Bladder
Etc.
Tight junctions do
Seal intercellular space from Lumina environment
What does it mean that tight junctions are not absolute
Means that their permeable to ions and other small molecules but not to macromolecules
What are the proteins used in tight junctions
Claudine and occulin
Cell to cell junctions depend on
Cadherin
Cadherin does what
Span the plasma membrane, with one end linking to the Cytoskeleton and the other end linking to structures outside of it
Adherence junctions are a type of
Cell to cell anchoring junctions
Adherence junctions are
Intermediate junctions or adhesion belt
Connect actin filament bundle of one cell to the ones in another cell
More basal than tight junction
Adherence junctions are found in
Epithelial cells
Cardiac muscle
Fibroblasts
What do adherence junctions provide to cytoskeleton
Anchorage site for cytoskeleton
Help modeling the shape of multicellular structures
Guides the organization of developing tissues
Important in tissue remodeling
Adherence junctions
What are desmosomes
Type of cell to cell adherence anchoring junction
What to desmosomes do (3)
Connect intermediate filaments from one cell to those in another
Provide anchorage site for cytoskeleton
Main function to provide mechanical strength
What is the main function of a desmosome
Provide mechanical strength
Where are desmosomes located
In tissues that suffer a lot of stress/stretch like skin intestine, stomach, bladder, etc
Gap junctions are a type of
Cell to cell junction
Gap junctions allow
The passage of small water soluble molecules from cell to cell without having to pass through the plasma membrane
Gap junctions are found where 3
Connective tissue
Epithelial tissue
Cardiac muscle
Etc
What are integrins
Transmembrane proteins
Cell to matrix junctions depend on
Integrins
Cell to matrix junctions are activated when
After binding Extracellular matrix legends or intercellular activator proteins
Cell to matrix produce
Intracellular signals that can influence almost any aspects cell behavior like proliferation, survival, polarity, or migration)
Cell to matrix anchoring junctions are 2
Actin linked cell matrix junction
Hemidesmosomes
Actin linked junctions are also known as
Focal adhesion
Actin linked junctions do what
Anchors actin filaments in cell to Extracellular matrix
Actin linked junctions can be
Small and transient
Large and durable
Hemidesmosomes anchor? Using?
Intermediate filaments in a cell to Extracellular matrix using integrins
Hemidesmosomes are found where
Epithelial cells connecting basal face of the basal lamina
