cell cycle control points

Question 1

what is the purpose of control points?

Answer 1

prevent mutant cell and cancer

Question 2

what will control points do when it detected DNA Damage?

Answer 2

repair or apoptosis

Question 3

After the start of gene transcription (DNA) it will be translated to ribosome which results to?

Answer 3

protein

Question 4

Cyclins + Cyclin Dependent kinases (CDK) = ?

Answer 4

Start of gene transcription (DNA)

Question 5

After undergoing to CDK and cyclins, cells will be expected to?

Answer 5

increase size, energy and protein produce, and formation of organelles.

Question 6

known as the “restriction checkpoint” because it stops cell division.

Answer 6

Gap 1 checkpoint

Question 7

how does gap 1 stops cell division?

Answer 7

pocket protein (transcriptional repressors)

Question 8

what are the pocket proteins (transcriptional repressors) of Gap 1?

Answer 8

RB, and P53

Question 9

What allows transcription to happen?

Answer 9

Transcription factor

Question 10

what is responsible for gene transcription to start?

Answer 10

E2F

Question 11

what is the 1st way to stop progression of G1 to S phase?

Answer 11

RB will bind to E2F

Question 12

what is the 2ND way to stop progression of G1 to S phase?

Answer 12

P53 will stimulate P21 which will inhibit CDK which will stimulate RB that will bind to E2F

Question 13

what are the pocket repressors of G2?

Answer 13

P53, ATM, CHK1, CHK2

Question 15

How to stop progression of G2 to M phase?

Answer 15

P53 plus ATM will stimulate CHK1 and CHK2

Question 16

known as “spindle checkpoint”, and delays progression of m phase to anaphase

Answer 16

Metaphase

Question 17

what is the progression of m phase to anaphase

Answer 17

Anaphase promoting complex (APC): PROTEIN SENSOR

Question 18

how does progression to m phase to a phase happen?

Answer 18

by the process of ubiquitination and proteolysis.