cell cycle control Flashcards
1
Q
if cells are metabolically active but not undergoing replication and have just come out of G1 what state are they in
A
G0
2
Q
protein degradation is controlled by what enzymes
A
ubiquitinases
3
Q
Ub = Ubiquitin (small peptide) E1 = ubiquitin activating enzyme E2 = ubiquitin conjugating enzyme E3 = Target specific ubiquitin ligase
A
addition of the residues marks proteins for degradation and performed by 3 classes of enzymes
Addition of ubiquitin tag to the protein
Degradation of the Taq protein in the proteozone
Ubiquitin activated by E1 which is ATP dependent
This activated molecules transfer to target molecule by E2 or E3
E1 and E2 enzymes are non specific
Specificity determined by E3 enzymes , ligates different substrates and times
4
Q
what stimulates the production of cyclins
A
mitogens or GF
