CC1 - TEST FOR CONJUGATION AND EXCRETION FUNCTION Flashcards
End product of hemoglobin metabolism
Principal pigm ent in bile
Bilirubin
Also formed from destruction of heme containing proteins such as myoglobin, catalase, and cytochromeoxidase
Are conjugated and excreted through the liver.
Bilirubin
Where does 85% of Bilirubin came from
heme of hemoglobin
Bilirubin 1
- Unconjugated bilirubin
- Water insoluble
- Nonpolar bilirubin
- Indirect bilirubin
- Hemobilirubin
- Slow reacting
- Prehepatic bilirubin
Bilirubin 2
- Conjugated bilirubin
- Water soluble
- Polar bilirubin
- Direct bilirubin
- Cholebilirubin
- One minute prompt bilirubin
- Post hepatic/ hepatic /obstructive/ regurgitative
bilirubin
If bilirubin synthesis > liver clearance rate =
increased bilirubin level
Plasma concentration of bilirubin increases upon birth and reaches its peak on
the 5th day
Conjugated bilirubin RV
0-0.2 mg/dL (0 3 umol/L)
Unconjugated bilirubin RV
0.2-0. 8 mg/dL (3-14 umol/L)
Total Bilirubin RV
0.2-1.0 mg /d L (3-17 umol/L)
- Conjugated bilirubin bound to albumin.
- They have longer half life
- It is formed due to prolonged elevation of conjugated bilirubin.
- This is an abnormal albumin.
- Helps in monitoring the decline of serum bilirubin
following cholecystectomy. - It reacts with diazo reagent.
Delta Bilirubin
Delta Bilirubin RV
<0.2 mg/dL
DB formula
For DB = TB DB+ IB should not be performed in
neonatal patients for less than or equal to 14 day s.