(9) Formation of Bilirubin

Question 1

Components of protein

Answer 1

CHON

Question 2

o Type of bilirubin formed / synthesized in the circulation.
o Bilirubin bound to albumin

Answer 2

B1/unconjugated:

Question 3

Bilirubin is a waste product, therefore, should be excreted.

Answer 3

o Bilirubin can only be excreted if it is converted into its conjugated form (B2).
o B2 is not normally found in circulation but very small amount (to none) of B2 leaks in the blood

Question 4

Enzyme responsible for conjugation of bilirubin

Answer 4

Uridine Diphosphate Glucoronyl / Glucoronosyl transferase (UDPGT):

Question 5

orange-colored product which gives stool its brown color.

Answer 5

Stercobilin:

Question 6

principal product that gives urine yellow color.

Answer 6

Urobilin

Question 7

In the past, icterus & jaundice are used interchangeably.

Answer 7

Fetus don’t develop jaundice; they develop it after birth.

Question 8

B1 can cross the blood-brain barrier (BBB) so it is toxic

Answer 8

→ leads to kernicterus

Question 9

Kernicterus:

Answer 9

o Bilirubin deposition in the brain.
o Causes severe motor dysfxn & retardation.

Question 10

Bilirubin most especially B1 are photosensitive.

Answer 10

tandaan

Question 11

Prehepatic jaundice disorders:

Answer 11

o HA
o G6PD def.

Question 11

Prehepatic jaundice disorders:

Answer 11

o HA
o G6PD def.

Question 12

Hepatic Unconjugated hyperbilirubinemia disorders:

Answer 12

o Gilbert’s
o Crigler-Najjar
o Lucey-Driscoll

Question 13

• Conjugated hyperbilirubinemia disorders:

Answer 13

o Dubin-Johnson
o Rotor syndrome

Question 14

can ONLY measure Direct/B2/Conjugated bilirubin & never B1.

Answer 14

Diazo reagents

Question 15

reacting, thus, needs accelerants.

Answer 15

IB/B1/Unconjugated bilirubin