Cardiovascular System Flashcards
Where is the heart located?
The thoracic cavity, medially between the lungs in the mediastinum
What separates the heart from the other mediastinal structures?
Pericardium/pericardial sac
How many chambers does the heart consist of?
Four: left & right atria, left & right ventricles
Which chambers act as the primary pumping chambers?
The left & right ventricles
What are the two main circuits of circulation?
Pulmonary circuit: transports blood to and from the lungs so it can pick up oxygen
Systemic circuit: transports oxygenated blood to the rest of the body
What does the right ventricle do?
Pumps deoxygenated blood into the pulmonary trunk which bifurcates into the left and right pulmonary arteries, which in turn become the pulmonary capillaries.
What is special about pulmonary trunk arteries?
They are the only arteries in the post-natal body that carry deoxygenated blood.
What is special about pulmonary veins?
They are the only post-natal veins that carry oxygenated blood.
What path does the oxygenated blood follow after the pulmonary veins?
Left atrium - left ventricle - the aorta - the branches of the systemic circuit - systemic capillaries - gas and waste exchange with the body tissues.
What path does the deoxygenated blood follow after delivering oxygen through the systemic capillaries?
The capillaries become venules - venules become veins - two major systemic veins: superior and inferior vena cava - right atrium - right ventricle
What is the fibrous pericardium made of?
Dense irregular connective tissue
What does the serous pericardium consist of?
-The parietal pericardium, fused to the fibrous pericardium
-The visceral pericardium/epicardium, fused to the heart (part of the heart wall)
Where does the pericardial cavity lie?
Between the epicardium and the pericardium
What are the three layers of the heart?
Epicardium, myocardium, endocardium
What does the outermost layer of the wall of the heart have in common with the innermost layer of the pericardium? What is it also known as?
They are the same structure, and is also known as the epicardium or the visceral pericardium
What is the middle layer of the heart? Describe its anatomy:
-The myocardium is the thickest layer of the heart, made mostly of cardiac muscle cells
-Built upon a framework of collagenous fibers that insulate the atria from the ventricles
-The contraction of the myocardium pumps blood through the heart
What is the innermost layer of the heart? Describe its anatomy:
-The endocardium lines the chambers where the blood circulates
-Made of simple squamous epithelium aka endothelium, continuous with the blood vessels
What is pericardial fluid?
A pleural fluid that lies in between the visceral and parietal layers of the heart, normally sterile, reduces friction caused by the constant movement of the heart
Why is the lumen smaller in the left ventricle?
Because the myocardium has to be much thicker to pressurize the blood enough to travel through the systemic circuit
What are atrioventricular valves?
Valves between the atria and ventricles
What are the semilunar valves?
Valves at the openings that lead to the pulmonary trunk and aorta
What is the difference between diastole and systole?
Diastole = relaxed
Systole = contracted
What is the difference between a tricuspid and a bicuspid valve?
Tri = three
bi = two
What do fluids flow according to?
Pressure gradients: from areas of high pressure to areas of lower pressure
What role does pressure play in the circulation of blood?
-during diastole the blood will flow into the atria from the veins (high to low pressure)
-the pressure in the atria rises during atrial systole and the blood moves into the ventricles (lower pressure)
-during ventricular systole the pressure rises and the blood flows into the pulmonary trunk from the right ventricle and into the aorta from the left
What are arteries and what is their purpose?
-Blood vessels that carry oxygenated blood away from the heart
-Branch until their smallest form, arterioles
-Arterioles deliver oxygen and nutrients to tissues
What are veins and what is their purpose?
Veins are lower pressure vessels than arteries, and carry deoxygenated blood and other waste materials to the heart and lungs
What is the lumen of blood vessels?
The hollow passageway through which blood flows
What are the three layers of blood vessels?
Inner: tunica intima
Middle: tunica media
Outer: tunica externa/adventitia
What are the three layers of an artery comprised of?
Tunica intima: endothelium, internal elastic membrane
Tunica media: smooth muscle, elastic fiber
Tunica externa: external elastic membrane, vasa vasorum, nervi vasorum
What are the three layers of a vein comprised of?
Tunica intima: endothelium
Tunica media: smooth muscle
Tunica externa: vasa vasorum and smooth muscle
What is the vasa vasorum?
a network of smaller blood vessels that supply the walls of large blood vessels, like elastic arteries and large veins
Why do veins in the outer limbs of the body have valves?
Being so far from the heart means the blood pressure is a lot lower, so the valves prevent the blood from flowing in the wrong direction, due to gravity or other factors
What is one of the primary causes of clot formation in blood vessels?
Damage to the endothelial lining exposing the blood to the collagenous fibers beneath
What is next to the endothelial tissue in blood vessels and what is its purpose?
-The basement membrane or basal lamina
-Binds the endothelium to the connective tissue
-Provides strength while maintaining flexibility
-Allows materials to pass through it
What type of connective tissue does the thin outer layer of the tunica intima contain?
Areolar tissue consisting primarily of elastic fibers for flexibility and collagenous fibers for strength
What are the valves in the veins of the outer limbs made of?
Sections of thickened endothelium reinforced with connective tissue
What is the thickest layer in arteries that is also much thicker in arteries than it is in veins?
The tunica media
What is the thickest layer in veins that is also usually thicker in veins than in arteries?
The tunica externa, aka the tunica adventitia
Describe the general purpose and anatomy of capillaries:
-Capillaries supply blood to the tissues through perfusion
-Walls are made of endothelial tissue surrounded by a basement membrane and occasionally smooth fibers
-Must allow substances to pass through them
What are the three major types of capillaries?
-Continuous
-Fenestrated
-Sinusoidal
What are continuous capillaries?
-The most common
-Complete endothelial lining with tight junctions between endothelial cells
-Ones not associated with the brain are rich in transport vesicles and contribute to either endocytosis or exocytosis
What are fenestrated capillaries?
-Contain fenestrations in addition to tight junctions in the endothelial lining
-Permeable to larger molecules
-Common in the small intestine and kidneys
What are sinusoid capillaries?
-Least common
-Flattened
-Extensive intercellular gaps
-Incomplete basement membranes
-Large openings allow for largest molecules (including plasma proteins and even cells)
-Found in the liver, spleen, bone marrow, lymph nodes, many endocrine glands
What is plasma?
-90% water
-10% dissolved proteins, amino acids, gases, electrolytes, sugars, hormones, lipids, vitamins
-Significant elements are albumin, immunoglobulins (antibodies) and fibrinogen
What is serum?
-Plasma without clotting factors
-Formed when blood is collected and induced to clot
-The conversion of fibrinogen to fibrin forms strands that trap all cellular elements
What are formed elements?
-Comprise 45% of blood volume
-99% RBC (red blood cells)
-Rest is WBC (white blood cells) and platelets
What are red blood cells?
-Carry hemoglobin
-An RBC circulates for about 120 days before being removed by the liver, bone marrow, or spleen
What are white blood cells?
-Protect the body against infection
-Most are in the peripheral tissues and lymphatic system at any given time
-Five types
What are the five types of WBC?
-Neutrophils
-Eosinophils
-Basophils
-Monocytes
-Lymphocytes
What are platelets?
-Created in the bone marrow from megakaryocytes
-Each one remains in circulation for 9-12 days
-Also called thrombocytes
What is hemostasis?
-The processes by which blood vessels are repaired after injury
What are the four phases of hemostasis?
-Vascular
-Platelet
-Coagulation
-Fibrinolysis
What is the vascular phase of hemostasis?
-Rupture of a blood vessel causes vascular spasm
(contraction of the smooth muscle lining the vessel)
-Reduces the diameter of the vessel, reducing blood loss
-Lasts about 30 minutes
What is the platelet phase of hemostasis?
-Aggregating platelets are activated
-Releasing factors that promote fibrin accumulation
-Combination of the vascular and platelet phase called primary hemostasis
-Exposure of materials beneath endothelial lining causes platelets to stick to the endothelial cells (adhesion)