Cardiovascular System Flashcards

1
Q

Where is the heart located?

A

The thoracic cavity, medially between the lungs in the mediastinum

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2
Q

What separates the heart from the other mediastinal structures?

A

Pericardium/pericardial sac

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3
Q

How many chambers does the heart consist of?

A

Four: left & right atria, left & right ventricles

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4
Q

Which chambers act as the primary pumping chambers?

A

The left & right ventricles

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5
Q

What are the two main circuits of circulation?

A

Pulmonary circuit: transports blood to and from the lungs so it can pick up oxygen
Systemic circuit: transports oxygenated blood to the rest of the body

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6
Q

What does the right ventricle do?

A

Pumps deoxygenated blood into the pulmonary trunk which bifurcates into the left and right pulmonary arteries, which in turn become the pulmonary capillaries.

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7
Q

What is special about pulmonary trunk arteries?

A

They are the only arteries in the post-natal body that carry deoxygenated blood.

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8
Q

What is special about pulmonary veins?

A

They are the only post-natal veins that carry oxygenated blood.

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9
Q

What path does the oxygenated blood follow after the pulmonary veins?

A

Left atrium - left ventricle - the aorta - the branches of the systemic circuit - systemic capillaries - gas and waste exchange with the body tissues.

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10
Q

What path does the deoxygenated blood follow after delivering oxygen through the systemic capillaries?

A

The capillaries become venules - venules become veins - two major systemic veins: superior and inferior vena cava - right atrium - right ventricle

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11
Q

What is the fibrous pericardium made of?

A

Dense irregular connective tissue

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12
Q

What does the serous pericardium consist of?

A

-The parietal pericardium, fused to the fibrous pericardium
-The visceral pericardium/epicardium, fused to the heart (part of the heart wall)

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13
Q

Where does the pericardial cavity lie?

A

Between the epicardium and the pericardium

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14
Q

What are the three layers of the heart?

A

Epicardium, myocardium, endocardium

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15
Q

What does the outermost layer of the wall of the heart have in common with the innermost layer of the pericardium? What is it also known as?

A

They are the same structure, and is also known as the epicardium or the visceral pericardium

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16
Q

What is the middle layer of the heart? Describe its anatomy:

A

-The myocardium is the thickest layer of the heart, made mostly of cardiac muscle cells
-Built upon a framework of collagenous fibers that insulate the atria from the ventricles
-The contraction of the myocardium pumps blood through the heart

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17
Q

What is the innermost layer of the heart? Describe its anatomy:

A

-The endocardium lines the chambers where the blood circulates
-Made of simple squamous epithelium aka endothelium, continuous with the blood vessels

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18
Q

What is pericardial fluid?

A

A pleural fluid that lies in between the visceral and parietal layers of the heart, normally sterile, reduces friction caused by the constant movement of the heart

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19
Q

Why is the lumen smaller in the left ventricle?

A

Because the myocardium has to be much thicker to pressurize the blood enough to travel through the systemic circuit

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20
Q

What are atrioventricular valves?

A

Valves between the atria and ventricles

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21
Q

What are the semilunar valves?

A

Valves at the openings that lead to the pulmonary trunk and aorta

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22
Q

What is the difference between diastole and systole?

A

Diastole = relaxed
Systole = contracted

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23
Q

What is the difference between a tricuspid and a bicuspid valve?

A

Tri = three
bi = two

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24
Q

What do fluids flow according to?

A

Pressure gradients: from areas of high pressure to areas of lower pressure

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25
Q

What role does pressure play in the circulation of blood?

A

-during diastole the blood will flow into the atria from the veins (high to low pressure)
-the pressure in the atria rises during atrial systole and the blood moves into the ventricles (lower pressure)
-during ventricular systole the pressure rises and the blood flows into the pulmonary trunk from the right ventricle and into the aorta from the left

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26
Q

What are arteries and what is their purpose?

A

-Blood vessels that carry oxygenated blood away from the heart
-Branch until their smallest form, arterioles
-Arterioles deliver oxygen and nutrients to tissues

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27
Q

What are veins and what is their purpose?

A

Veins are lower pressure vessels than arteries, and carry deoxygenated blood and other waste materials to the heart and lungs

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28
Q

What is the lumen of blood vessels?

A

The hollow passageway through which blood flows

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29
Q

What are the three layers of blood vessels?

A

Inner: tunica intima
Middle: tunica media
Outer: tunica externa/adventitia

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30
Q

What are the three layers of an artery comprised of?

A

Tunica intima: endothelium, internal elastic membrane
Tunica media: smooth muscle, elastic fiber
Tunica externa: external elastic membrane, vasa vasorum, nervi vasorum

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31
Q

What are the three layers of a vein comprised of?

A

Tunica intima: endothelium
Tunica media: smooth muscle
Tunica externa: vasa vasorum and smooth muscle

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32
Q

What is the vasa vasorum?

A

a network of smaller blood vessels that supply the walls of large blood vessels, like elastic arteries and large veins

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33
Q

Why do veins in the outer limbs of the body have valves?

A

Being so far from the heart means the blood pressure is a lot lower, so the valves prevent the blood from flowing in the wrong direction, due to gravity or other factors

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34
Q

What is one of the primary causes of clot formation in blood vessels?

A

Damage to the endothelial lining exposing the blood to the collagenous fibers beneath

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35
Q

What is next to the endothelial tissue in blood vessels and what is its purpose?

A

-The basement membrane or basal lamina
-Binds the endothelium to the connective tissue
-Provides strength while maintaining flexibility
-Allows materials to pass through it

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36
Q

What type of connective tissue does the thin outer layer of the tunica intima contain?

A

Areolar tissue consisting primarily of elastic fibers for flexibility and collagenous fibers for strength

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37
Q

What are the valves in the veins of the outer limbs made of?

A

Sections of thickened endothelium reinforced with connective tissue

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38
Q

What is the thickest layer in arteries that is also much thicker in arteries than it is in veins?

A

The tunica media

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39
Q

What is the thickest layer in veins that is also usually thicker in veins than in arteries?

A

The tunica externa, aka the tunica adventitia

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40
Q

Describe the general purpose and anatomy of capillaries:

A

-Capillaries supply blood to the tissues through perfusion
-Walls are made of endothelial tissue surrounded by a basement membrane and occasionally smooth fibers
-Must allow substances to pass through them

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41
Q

What are the three major types of capillaries?

A

-Continuous
-Fenestrated
-Sinusoidal

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42
Q

What are continuous capillaries?

A

-The most common
-Complete endothelial lining with tight junctions between endothelial cells
-Ones not associated with the brain are rich in transport vesicles and contribute to either endocytosis or exocytosis

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43
Q

What are fenestrated capillaries?

A

-Contain fenestrations in addition to tight junctions in the endothelial lining
-Permeable to larger molecules
-Common in the small intestine and kidneys

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44
Q

What are sinusoid capillaries?

A

-Least common
-Flattened
-Extensive intercellular gaps
-Incomplete basement membranes
-Large openings allow for largest molecules (including plasma proteins and even cells)
-Found in the liver, spleen, bone marrow, lymph nodes, many endocrine glands

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44
Q

What is plasma?

A

-90% water
-10% dissolved proteins, amino acids, gases, electrolytes, sugars, hormones, lipids, vitamins
-Significant elements are albumin, immunoglobulins (antibodies) and fibrinogen

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45
Q

What is serum?

A

-Plasma without clotting factors
-Formed when blood is collected and induced to clot
-The conversion of fibrinogen to fibrin forms strands that trap all cellular elements

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46
Q

What are formed elements?

A

-Comprise 45% of blood volume
-99% RBC (red blood cells)
-Rest is WBC (white blood cells) and platelets

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47
Q

What are red blood cells?

A

-Carry hemoglobin
-An RBC circulates for about 120 days before being removed by the liver, bone marrow, or spleen

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48
Q

What are white blood cells?

A

-Protect the body against infection
-Most are in the peripheral tissues and lymphatic system at any given time
-Five types

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49
Q

What are the five types of WBC?

A

-Neutrophils
-Eosinophils
-Basophils
-Monocytes
-Lymphocytes

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50
Q

What are platelets?

A

-Created in the bone marrow from megakaryocytes
-Each one remains in circulation for 9-12 days
-Also called thrombocytes

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51
Q

What is hemostasis?

A

-The processes by which blood vessels are repaired after injury

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52
Q

What are the four phases of hemostasis?

A

-Vascular
-Platelet
-Coagulation
-Fibrinolysis

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53
Q

What is the vascular phase of hemostasis?

A

-Rupture of a blood vessel causes vascular spasm
(contraction of the smooth muscle lining the vessel)
-Reduces the diameter of the vessel, reducing blood loss
-Lasts about 30 minutes

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54
Q

What is the platelet phase of hemostasis?

A

-Aggregating platelets are activated
-Releasing factors that promote fibrin accumulation
-Combination of the vascular and platelet phase called primary hemostasis
-Exposure of materials beneath endothelial lining causes platelets to stick to the endothelial cells (adhesion)

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55
Q

What is the coagulation phase of hemostasis?

A

-Cascade of enzymes and factors that result in a blood clot

56
Q

What is the fibrinolysis phase of hemostasis?

A

-Controlled by plasmin
-As the wound is closed and tissue repair commences, fibrin itself is broken down slowly

57
Q

What does angi/o mean?

A

Vessel

58
Q

What does aort/o mean?

A

Aorta

59
Q

What does arteri/o mean?

A

Artery

60
Q

What does arteriol/o mean?

A

Arteriole

61
Q

What does cardi/o mean?

A

Heart

62
Q

What does coron/o mean?

A

Heart

63
Q

What does phleb/o mean?

A

Vein

64
Q

What does ven/o mean?

A

Vein

65
Q

What does venul/o mean?

A

Venule

66
Q

What is an aneurysm?

A

Local widening of an artery caused by weakness in the arterial wall or breakdown of the wall from atherosclerosis

67
Q

What is angina?

A

Chest pain caused by decreased blood flow to the heart muscle, aka angina pectoris (pect/o meaning chest)

68
Q

What is arrhythmia?

A

Abnormal heartbeat rhythm, e.g. fibrillation or flutter

69
Q

What is artherosclerosis?

A

Hardening of arteries with a collection of cholesterol-like plaque

70
Q

What is congestive heart failure?

A

Inability of the heart to pump its required amount of blood, blood accumulates in the lungs, causing pulmonary edema

71
Q

What is hypertension?

A

High blood pressure
Essential hypertension is without apparent cause
Secondary is caused by another illness

72
Q

What is myocardial infarction?

A

Heart attack (an infarct is an area of necrotic tissue)

73
Q

What is shock?

A

A group of symptoms (paleness, weak pulse, shallow breathing) indicating poor oxygen supply to tissues and insufficient return of blood flow to the heart

74
Q

What is an angiography?

A

Recording via x-ray blood vessels after the injection of contrast into the blood stream

75
Q

What is cardiac catheterization?

A

Introducing a catheter into a coronary blood vessel to measure pressure and flow patterns

76
Q

What are cardiac enzyme tests?

A

Measurements of enzymes released into the blood stream after an MI

77
Q

What is a doppler ultrasound?

A

Measuring blood flow in vessels via sound waves

78
Q

What is echocardiography?

A

Images of the heart produced using sound waves

79
Q

What is electrocardiography?

A

Recording electricity flowing through the heart

80
Q

What is holter monitoring?

A

Detection of abnormal heart rhythms (arrhythmias) that involves having the patient wear a compact version of an electrocardiograph for 24 hours

81
Q

What are lipid tests?

A

Measurements of cholesterol and triglyceride levels in the blood

82
Q

What are lipoprotein tests?

A

Measurements of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) in the blood

83
Q

What is magnetic resonance imaging?

A

Producing an image by beaming magnetic waves at the heart to give detailed information about congenital heart disease, cardiac masses, and large blood vessel diseases

84
Q

What is a MUGA scan?

A

Imaging the motion of the heart wall muscles and assessing the function of the heart via a multiple-gated acquisition scan, which uses radioactive chemicals

85
Q

What is positron emission tomography?

A

A PET scan is radioactive particles injected into the blood stream and into the heart to acquire cross-sectional images of the flow of blood and functional activity of the heart

86
Q

What is a stress test?

A

An electrocardiogram + blood pressure + heart rate measurements showing the heart’s response to physical exertion using a treadmill

87
Q

What is a technetium Tc 99m sestamibi scan?

A

A radioactive pharmaceutical is injected intravenously to show perfusion of blood in the heart muscle. It is taken up in the area of an MI producing “hot spots”

88
Q

What is a thallium-201 scan?

A

A radioactive test that shows where injected thallium-201 (radioactive substance) localizes in the heart muscle

89
Q

What is a cardiac catheter ablation?

A

Flexible tube threaded through blood vessels into the heart to destroy (ablate) abnormal tissue causing arrhythmias

90
Q

What is cardioversion?

A

Brief discharges of electricity passing across the chest to stop a cardiac arrhythmia, aka defibrillation

91
Q

What is coronary artery bypass grafting?

A

A CABG is when vessels are taken from the patient’s legs or chest and connected to coronary arteries to make detours around blockages

92
Q

What is an endarterectomy?

A

Surgical removal of the innermost lining of an artery to remove fatty deposits and clots

93
Q

What is a heart transplant?

A

A donor heart is transferred to a patient whose own heart cannot sustain them

94
Q

What is percutaneous coronary intervention?

A

PCI is a balloon-tipped catheter threaded into a coronary artery to compress fatty deposits and open the artery. Stents create wider openings that make the recurrence of blockages less likely

95
Q

What is thrombolytic therapy?

A

Drugs such as tPA (tissue plasminogen activator) and streptokinase are injected into a patient’s bloodstream to dissolve clots that may cause a heart attack

96
Q

What does ACS stand for?

A

Acute Coronary Syndrome

97
Q

What does AED stand for?

A

Automated External Defibrillator

98
Q

What does AMI stand for?

A

Acute Myocardial Infarction

99
Q

What does BP stand for?

A

Blood pressure

100
Q

What does CABG stand for?

A

Coronary Artery Bypass Grafting

101
Q

What does CAD stand for?

A

Coronary Artery Disease

102
Q

What does CCU stand for?

A

Coronary Care Unit

103
Q

What does CHF stand for?

A

Congestive Heart Failure

104
Q

What does CPR stand for?

A

Cardiopulmonary Resuscitation

105
Q

What does ECG stand for?

A

Electrocardiography

106
Q

What does ECHO mean?

A

Echocardiography

107
Q

What does HDL stand for?

A

High-Density Lipoprotein

108
Q

What does HTN stand for?

A

Hypertension

109
Q

What does ICD stand for?

A

Implantable cardioverter-defibrillator

110
Q

What does LDL stand for?

A

Low-Density Lipoprotein

111
Q

What does PCI stand for?

A

Percutaneous Coronary Intervention

112
Q

What type of tissue is shown in this image?

A

Cardiac muscle (cardiac myocytes)

113
Q

What is being pointed to in this image?

A

Intercalated disks

114
Q

What is this an image of?

A

Elastic artery

115
Q

What does this image depict?

A

The tunica intima of an elastic artery

116
Q

What does this image depict?

A

Tunica media of an elastic artery

117
Q

What does this image depict?

A

Tunica adventitia of an elastic artery

118
Q

What is this an image of?

A

Large vein

119
Q

What does this image depict?

A

Tunica intima of a large vein

120
Q

What is depicted in this image?

A

The small tunica media of a large vein

121
Q

What is depicted in this image?

A

Tunica adventitia of a large vein

122
Q

What does this image depict?

A

Top: muscular (distributing) artery
Bottom: medium vein (companion to the muscular artery, fewer distinct layers)

123
Q

What does this image depict?

A

Vein valve

124
Q

What is depicted in this image?

A

Sinusoid capillaries

125
Q

Name the cell depicted here:

A

RBC

126
Q

Name the cell depicted here (excluding RBCs):

A

Platelets

127
Q

Name the cell depicted here (excluding RBCs):

A

Neutrophil

128
Q

Name the cell depicted here (excluding RBCs):

A

Eosinophil

129
Q

Name the cell depicted here (excluding RBCs):

A

Basophil

130
Q

Name the cell depicted here (excluding RBCs):

A

Lymphocyte (large)

131
Q

Name the cell depicted here (excluding RBCs):

A

Lymphocyte (small)

132
Q

Name the cell depicted here (excluding RBCs):

A

Monocyte

133
Q

What is the function of neutrophils?

A

-As phagocytes, they attack and digest bacteria
-Usually the first WBC on the scene of an infection
-Lifespan of only 3-4 days

134
Q

What is the function of eosinophils?

A

-Phagocytic
-Target parasites and antibody-labeled foreign molecules rather than cells

135
Q

What is the function of basophils?

A

-Phagocytic
-Release histamine
-Produce heparin
-Increased basophils can indicate leukemia

136
Q

What is the function of lymphocytes?

A

-Mostly reside in lymph nodes
-Circulate between lymphatic and circulatory systems
-Include B cells (produce antibodies)
-Include natural killer (NK) cells (destroy foreign and infected cells)
-Include T cells (control cellular immunity)

137
Q

What is the function of monocytes?

A

-Large phagocytic cells
-Pass from the circulatory system to the peripheral tissues
-Then transform into macrophages and act as roving sentries
-Signal to activate B cells to create antibodies

138
Q

What is the function of platelets?

A

-Also called thrombocytes
-Play a critical role in blood coagulation