Cardiopulm Unit 8 Obstructive Lung Diseases Flashcards
Using Spirogram, a person with normal lungs, how long does it take them to reach 4 L (in volume) and what is the FEV1/FVC?
- Takes about 4 seconds
- FEV1/FVC = 75%
Using Spirogram, a person with obstructive lungs, how long does it take them to reach 4 L (in volume) and what is the FEV1/FVC?
- Takes about 7 seconds
- FEV1/FVC = 25%
What is the difference between normal and obstructive lungs in terms of Total Lung Capacity and Residual Volume?
Both are higher with the obstructive lungs
- Residual Volume is a key characteristic finding with obstructive lung disease
What is COPD?
A progressive disease which features chronic airflow limitations that are typically caused by a mixture of parenchymal alveolar disease (emphysema) and small-airway disease (obstructive bronchiolitis) which commonly occur in combination, with proportions varying from individual to individual. However, in some cases, either emphysema or chronic bronchitis is clearly dominant
Parenchymal: functional tissue of an organ (e.g. lung alveoli) as distinguished from the connective and supporting tissue
What are the 2 Primary Causes of COPD?
- Inhalation Factors
- Genetics
The Pathophysiology of COPD includes what? What do these 4, all do?
- Hyperplasia of the mucus-secreting cells
- Reactive airways
- Terminal bronchiole destruction
- Alveolar sac destruction
All of which reduce airflow out of the air sacs and the airways and result in hyperinflation and poor gas exchange resulting in ventilation/perfusion (V/Q) mismatch, hypoxemia, and oftentimes hypercapnia
With COPD, what is Inhalation Exposure?
How can smoking impair the lungs?
Inhalation exposure is often the primary contributing factor to the cascade of airway and alveoli inflammatory responses that lead to disease, especially in genetically susceptible individuals.
Cigarette smoke impairs cilia function, and alveolar macrophages within the lung parenchyma can be permanently destroyed, increasing the risk of infection
With Inhalation Exposure, what else may result from its inflammatory response? How long will the inflammatory response take?
May result in Infection, which increases the progression of lung destruction
- Inflammatory response will continue as long as the inhalation exposure occurs, and if long-term exposure has occurred, the inflammatory damage may not be reversible despite smoking cessation or removal of the inhalation exposure.
With Obstructive lung disease, what is the Vicious Cycle Hypothesis?
- This starts off with an initiating factor (e.g., smoking, childhood repsiratory disease)
- Leads to impaired innate lung defense, which exposes the lungs to infection, microbial colonization
- If the Microbial Colonization becomes large enough and the immune system responds, the body creates Microbial Antigens
- This then leads to Airway Epithelial injury, which will further damage the innate lung defense
And the cycle will continue to worsen
With the Vicious Cycle Hypothesis, what happens in the cycle if the person with COPD has an Acute Exacerbation?
- This will lead to an inflammatory response
- Leading to increased proteolytic activity
- Leading to Altered proteinase anti-proteinase balance
- Which will lead to the progression of COPD, and cause airway epithelial injury and further impair the innate lung defense
With the GOLD Staging of COPD, what is stage 1?
COPD Severity, FEV1/FVC ratio, FEV range
- COPD Severity: Mild
- FEV1/FVC Ratio: < 0.70
- FEV Range: ≥ 80% of normal
With the GOLD Staging of COPD, what is stage 2?
COPD Severity, FEV1/FVC ratio, FEV range
- COPD Severity: Moderate
- FEV1/FVC Ratio: < 0.70
- FEV Range: 50 - 79% of normal
With the GOLD Staging of COPD, what is stage 3?
COPD Severity, FEV1/FVC ratio, FEV range
- COPD Severity: Severe
- FEV1/FVC Ratio: < 0.70
- FEV Range: 30 - 49% of normal
With the GOLD Staging of COPD, what is stage 4?
COPD Severity, FEV1/FVC ratio, FEV range
- COPD Severity: Very Severe
- FEV1/FVC Ratio: < 0.70
- FEV Range: ≤ 30% of normal OR < 50% of normal with chronic respiratory failure present
What are the Characteristics Emphysema-Dominant Phenotype of COPD (“Pink Puffer”)?
- Typically characterized by a thin appearance due to weight loss, which is a result of the increased energy expenditure from the effort of breathing.
- May appear to be taking more effort to breathe, Using accessory muscles to compensate for impaired diaphragmatic function secondary to lung hyperinflation.
- Lips and nail beds may not show signs of cyanosis hence the term “pink”, which indicates relatively well- oxygenated blood despite the difficulty in breathing.
- The “puffer” part of the term comes from the pursed-lip breathing that alters respiratory mechanics by increasing airway pressure, which helps to prevent airway collapse during expiration
What are the Characteristics Bronchitis-Dominant Phenotype of COPD (“Blue Bloater”)?
- Exhibit persistent coughing and produce large amounts of sputum
- Typically presents with an overweight body type due to a combination of factors including a reduction in exercise capacity and the body’s attempt to increase its oxygen reserve capacity.
- Often exhibit signs of cyanosis, which gives rise to the term “blue”.
- The term “bloater” refers to the bloating seen in the body, including potential fluid retention and swelling, particularly in the lower extremities, due to right-sided heart failure that can complicate chronic bronchitis.
What do Mucous Plugs and Unstable Airways cause?
- Air trapping and hyperinflation on expiration
- During Inspiration, the airways are pulled open, allowing gas to flow past the obstruction
Emphysema
During Expiration, what does decreased elastic recoil of the bronchial walls result in?
Results in collapse of the airways and prevents normal expiratory flow
Emphysema
What is Flattened Hemi-Diaphragmatic contours considered?
- When is this best seen?
Its considered on of the most sensitive indicators of Hyperinflation
- Best seen on the lateral chest radiograph and consist of a loss of height of the convexity of the hemidiaphragm
- Draw a line connecting the sternophrenic angle and this arch height should be ≥2.5 cm
- It is considered clearly pathological when measured less than 1.5 cm
How is Muscle Composition affected with COPD?
- There is a shift from Type 1 to Type 2 Skeletal muscle fibers.
- There is a reduction in aeroic metabolism and poor muscle endurance
Those with COPD that have decreases in strength of both skeletal and respiratory musculature are associated with what?
Independently associated with poorer exercise capacity and lower extremity functioning across the spectrum of COPD severity
Emphysema
With the Diaphragam, what happens as the diaphragm flattens?
Its ability to contract and relax affects the individuals ability to perform a normal passive exhalation
Emphysema
As COPD progresses, how can it affect the diaphragam and Pelvic Floor?
As the disease progresses, exhalation can become forced instead of passive, increasing intraabdominal pressure and putting more stress on the pelvic floor. This can lead to pelvic floor dysfunction that can manifest as urinary incontinence in both males and female
What are the Clinical Manifestations for Emphysema?
- Use of Accessory Muscles to breath
- Pursed-Lip breathing
- Minimal or absent cough
- Leaning forward to breath
- Dyspnea on exertion (late sign)