Cardiac Flashcards
The sinoatrial node is located where and which cells are the main pacemaker?
Located in right atrium and P cells are the main pacemaker
Which abnormalities can lead to electrical alternans ?
Decreased calcium/K/Mg, amiodarone, HCM, CHF, TE
Which diseases can cause delayed repolarization and why is it bad?
Congenital (mutation of sodium or potassium channels) vs acquired (decreased Mg, K or Ça)
Can increase susceptibility to arrhythmia
What are the characteristics of A-fib ?
Absence of P wave, tachycardia and normal but irregular QRS
Which factors can cause vasodilation?
Adenosine, CO2, potassium, H+, histamine and NO
Which hormones are the most powerful for vasoconstriction?
Vasopressin > Angiotensin II > norepinephrine
Which ions causes vasoconstriction?
Calcium
Which nutrient does the heart consumes (as opposed to other systems)
Fatty acid instead of carbohydrates
Is calcium more present inside or outside the cell?
Extracellular
What happens at the neuromuscular junction?
Entry of calcium –> release Ach –> opens ions channels (Na,K, Ça) on post-synaptic membre –> action potential –> anticholinesterase destruct Ach –> résorbe choline
Which drugs can cause bradycardia?
Opioid, a2-agonist, B-adrenergic/calcium channel blockers (diltiazem, digoxin or sotalol)
What are the causes of sick sinus syndrome?
Mutation (in sodium channels or smooth muscles), fibrosis, dysfunction of ryanodine receptor)
What are the changes seen on ECG for atrial standstill and what is the treatment?
No P wave, only escape beats.
Ventricular pacemaker
Which treatment can be given for neurocardiogenic bradycardia mediated by cardiac C fibers?
Hyoscyamine/propantheline, theophylline (antagonist A1 adenosine receptor), terbutaline (acts on B1 receptor to increase parasympathetic tone) or isoproterenol (non selective B adrenergic receptors)
DCM is due to a mutation in which gene for which breed?
Pyruvate dehydrogenase kinase 4 in doberman
What can be heard on auscultation in DCM?
Low grade systolic left apical murmur with S3
Which disease is associated with a genetic deletion mutation in the 3’ untranslated region of striatin
ARVC
What are the 3 components of the virchow’s triad ?
Stasis, vessel wall injury and hypercoagulable state
Which change can be seen on radiographs with heartworm?
Enlarged caudal pulmonary artery
Do cats have evidence of microfilaria in HW disease?
No - 60% are not microfilaremic
What are the 2 ways to test for HW with ELISA?
Antigen that detects reproductive tract of adult female
Antibodies against L4 exposure