Cancer drugs Flashcards
Magic mouthwash indications and NC
- stomatitis
- swish and spit or swish and swallow 5-10mL q6h PRN
- not curative
Cytotoxic agents MOA
cause cell death by disrupting mitosis and DNA synth; target rapidly prolif cells
- vesicants
- best thru CVC or port
hormonal chemo agent MOA
Block hor effect on tumors; Anti-estrogen
Biologics MOA and indications
Stim immune sys to respond stronger to cancer
- leukemias, breast, bladder, brain, colon, lung, pancreas cancer
Biologics SE
Pain, swell, sore, flu-like, wet gain, diarrhea, risk infx
Types of biologics
immune checkpoint inhibitors, t-cell transfer therapy, monoclonal antibodies, tx vax, immune sys modulators
Targeted chemo drugs
attach the cancer cell itself
Cyclophosphamide class and MOA
- Alkylating agent
- Cell cycle non specific
Cyclophosphamide SE and NC
Usual tox plus vesicant, hemorrhagic cystitis, sterility, discoloration of skin and nails, bladder injury
- prob with resistance
Methotrexate class, indications, and MOA
- Antimetabolites
- Leukemia and some lymphomas
- Replace normal metabolites and kill cell; cell cycle specific; interfere with S phase
Methotrexate SE and NC
- Usual and nephro, hepatotoxic, fetal death abnormality
- resistance prob
Doxorubicin class and MOA
- antitumor abx
- cell cycle non specific
Doxorubicin SE and NC
- Usual plus cardiotox and makes urine reddish, EKG changes
- acute or delayed rxn
- ⅓ women get HF
- ”red devil” or “red death”
Vincristine class, MOA, and NC
- mitotic inhibitors: vinca alkaloid
- NO bone marrow supp, peripheral neuropathy, vesicant
- cell cycle specific
vincristine NC
- good for combo
- serviced from periwinkle plan
