C8.2 - Microbial Interference and Surface Virulence Flashcards
Type of Interference - Streptococci
Kill Phagocyte
Inhibit Chemotaxis
Resist phagocytosis
Resist digestion
Kill phagocyte (Streptococci)
Streptolysin induces lysosomal discharge into cell cytoplasm
Inhibit chemotaxis (Streptococci)
Streptolysin
Resist phagocytosis (Streptococci)
M substance
Type of Interference - Staphylocci
Kill phagocyte
Inhibit opsonization
Resist killing
Kill phagocyte (Staphylococci)
Leukocidin induces lysosomal discharge into cell cytoplasm
Inhibit opsonization (Staphylococci)
Protein A blocks Fc portion of Ab
Resist killing (Staphylococci)
Cell wall mucopeptide
Bacillus anthracis - Type of Interference
Kill phagocyte
Resist killing
Kill phagocyte (Bacillus anthracis)
Toxic complex
Resist Killing (Bacillus anthracis)
Capsular polyglutamic acid
Resist phagocytosis (unless Ab present) (Haemophilus influenzae)
Polysaccharide capsule
Resist phagocytosis (unless Ab present) - Pseudomonas aeruginosa
“Surface slime” (polysaccharide)
Klebsiella pneumoniae - Type of Interference
Resist Digestion
Resist phagocytosis (unless Ab present) - E. coli
O antigen (smooth strains) and K antigen (acid polysaccharide)
Resist killing (E. coli)
K antigen
Resist phagocytosis (unless Ab present) - Salmonella typhi
Vi antigen
Resist phagocytosis (Cryptococcus neoformans)
Polysaccharide capsule
Resist phagocytosis (Treponema pallidum)
Cell Wall
Resist killing (Yersinia pestis)
Protein-carbohydrate cell wall
Resist killing and digestion (Mycobacteria)
Cell Wall Structure
Resist killing (Brucella abortus)
Cell wall substance
Streptococcus pneumonia - Virulence Factor and Used in Vaccine (Yes/No)
Polysaccharide capsule - YES
Streptococcus pyogenes - Virulence Factor and Used in Vaccine (Yes/No)
M protein - NO
Staphylococcus aureus - Virulence Factor and Used in Vaccine (Yes/No)
Protein A - NO
Neisseria meningitides - Virulence Factor and Used in Vaccine (Yes/No)
Polysaccharide capsule - YES
Bacillus anthracis - Virulence Factor and Used in Vaccine (Yes/No)
Polypeptide capsule - NO
Haemophilus influenzae - Virulence Factor and Used in Vaccine (Yes/No)
Polysaccharide capsule - YES
Klebsiella pneumoniae - Virulence Factor and Used in Vaccine (Yes/No)
Polysaccharide capsule - NO
Escherichia coli - Virulence Factor and Used in Vaccine (Yes/No)
Protein pili -NO
Salmonella typhi - Virulence Factor and Used in Vaccine (Yes/No)
Polysaccharide capsule - NO
Yersinia pestis -Virulence Factor and Used in Vaccine (Yes/No)
V and W proteins - NO
