Brain et al Blood Supply Flashcards
what does ‘lesion of brain’ really mean?
strokes or injury to brain tissue
what arteries create the anastomosis of the brain and circle of Wilis?
2 internal carotid arteries and 2 vertebral arteries
WHERE is the Circle of Wilis located?
on the ventral surface of the brain in the subarachnoid space
Berry (saccular) Aneurysm location?
at the furcation of the basilar artery
weakness in vessels is common?
in areas where there is a bifurcation
Clinical correlate to Berry Aneurysm
- causes a stroke when is ruptures
- presented as “worst headache of life”
- sac like out-pouching in basilar cerebral vessel
subarachnoid hemorrhage caused from? location?
rupture of cerebral artery
*between pia and arachnoid mater (arachnoid mater is between pia and dura)
subarachnoid hemorrhage is usually results from?
rupture of cerebral artery
Protein circulating the blood enter most tissues of the body except those of the?
brain, spinal cord, or peripheral nerves
*blood supply to brain is HIGHLY regulated
blood supply to brain is regulated by?
blood brain barrier
what are the blood brain barrier cells/proteins?
1) endothelial cells
2) pericytes
3) astrocytic
endothelial cells have ____ junctions between them?
tight junctions
describe pericytes? what do they surround?
- surround capillaries on the SIDE; not completely
* elongated, contractile cells found wrapped about precapillary arterioles outside the basement membrane
Astrocytic processes surround? do what?
sompletly surround cerebral capilarries
*support CNA
describe capillaries in brain
purpose is for gas exchange between veins and arteries; typically open in other parts of body, have A LOT of tight junctions in brain to prevent/regulate exchange
*Dependent on tight junctions between
endothelial cells (couple with lack of
transcytotic vesicular transport).
