BP + Kidney Flashcards
How is BP calculated?
BP = CO * TPR
How is CO calculated?
CO = HR * SV
What is the cardiovascular response to low blood pressure?
Decrease preload -> decrease cardiac stretch -> decrease stroke volume
Activation of carotid sinus baroreceptors -> increased sympathetic activity
Increased sympathetic activity
- Increase heart rate
- increase contractility -> increase stroke volume
- constrict afferent arterioles -> increase SVR
What can cause renin release from the kidney?
Sympathetic stimulation of JGA
Reduced renal blood flow detected by baroreceptors in JGA
Reduced NaCl to JGA
Where is the JGA?
In the DCT
What cells make up the JGA?
Macula densa cells
What is the role of renin?
Converts angiotensinogen to angiotensin 1
Where is angiotensinogen produced?
Liver
What is angiotensin 1 converted to?
Angiotensin 2
What catalyses the conversion of angiotensin 1?
ACE
Where is ACE produced?
Lungs
Kidney
What is the role of angiotensin 2?
Increases sympathetic activity Increases aldosterone secretion Increases NaCl reabosorption Causes arteriolar vasoconstriction Stimuates ADH secretion
What is the role of aldosterone?
Upregulates Na/K pump in the DCT Upregulates Na channels in the CD Stimulates secretion of K into tubule Stimulates H+ secretion in CD Upregulates NaCl cotransporter in DCT
Where is ADH secreted from?
Anterior pituitary
What is the role of ADH?
Removes aquaporins from CD
Causes vasoconstriction
