BMP: Drug Design 3

Question 1

What is the electron configuaratino of nitrogen if its atomic number is 7?

Answer 1

1s2 2s2 2p3

Question 2

Revise Hybridisation sheet and geometry sheet

Question 3

What are the following for this compound NH4+:

1. hybridisation
2. Bond Angles
3. Geometry

Answer 3

1. SP3
2. 109.5
3. tetrahedral

Question 4

What is are the following for NH3:

1. Hybridisation
2. Angles
   
   1. What causes the diffrerence in angle?
3. Geomertry

Answer 4

1. SP3
2. 107
   
   1. The lone pair of electrons exerts an electrosotic replusive forces pusjing the electrons further away and causing bond angles to decrease
3. Trigonal pyrimidal

Question 5

1. When is a reaction favourable?
2. At equilibrium which acid is produced?
3. In terms of pKa what indictes a stronger acid?

Answer 5

1. When K>0
2. Weaker
3. lwoer

Question 6

What effects the physiochemical properties and ionisation of nitrogen?

Answer 6

1. 1,2,3 groups can effected the water solubilty of nitrogen
2. the number and size ofsubstituent groups can cause sterric hinderous to lone pair
3. EWG and EDG groups effect the availbiilty of the lone pair

Question 7

What is the difference in pKas of arylamines and alkylamines? What does this mean in trms of basicity? why?

Which is more stable?

What effects the basicity of aniilne?

Answer 7

1. Alkylamines have a lower pKa therefore are less basic.

This is due to the Nitrogen lone pair being delocalised and involved with the pi-electron cloud/ system therefore less available for bonding

1. However, due to the 5 resosonance structures that can bedrawn for arylamines, they are more stable
2. EWG and EDG

Question 8

Discuss the basicity of these amines

Answer 8