Blood Cells & Coagulation Part 2- 2 Flashcards
What do blood platelets release when they adhere to collagen fibers in the wall of an injured vessel?
ADP and TXA2 (thromboxane A2)
What does the ADP and TXA2 increase that will aggregate the sealing of the injured vessel?
Platelet adhesiveness
What do normal endothelium release for the adhesiveness of blood platelets?
Prostacyclin and Nitric oxide
What is initially loosely constructed, but shortly after vessel injury, the blood starts to coagulate forming a lattice of fine fibrine threads in and around it?
Platelet plug
What coagulation cascade occurs when blood comes into contact with collagen fibers or white surfaces other from endothelium?
Intrinsic activation
What coagulation cascade is triggered by a tissue factor not present in the blood but released from surrounding tissues upon tissue damage?
Extrinsic activation
What does blood coagulation require?
Ca++
What does the intrinsic pathway start with?
Collagen
What factor is used in the intrinsic pathway that contributes to X in extrinsic pathway?
IX
What factor in the extrinsic pathway is used with prothrombin to make thrombin?
X activated
What is used with fibrinogen to make fibrin, the end product of the cascade coagulation
Thrombin
What is the limiting step of the coagulation cascade because its what helps convert prothrombin to thrombin?
X inactive
What are components of RBCs plasma membrane?
Blood groups antigens
What are AB0 blood group antigens?
Glycosphingolipids
What antigen is GaINAc the end product of?
A-antigen
