Blood Cells And Coagulation Part 1- 2 Flashcards
Hb can __________ bind to oxygen without changing the valance
Reversibly
How many subunits does hemoglobin consist of?
4
Each subunit of hemoglobin contains a ________ peptide chain, and a ____ group that contains _____ on its center
Globular
Heme
Iron
What is the formation of blood cells?
Hematopoiesis
What is the formation of red blood cells?
Erythropoiesis
Where does erythropoiesis occur by the division of stem cells during fetal life?
Liver and spleen
Where does erythropoiesis occur by the division of stem cells from brith until adolescence?
Red bone marrow of long bones
Where does erythropoiesis occur by the division of stem cells from adolescence onwards?
Red bone marrow of flat bones
What is the name of the single cell type in the bone marrow where are all blood cells derived from?
Pluripotent stem cell
After some cell division, which 2 cells become predestined into differentiate into erythrocytes?
Pro-erythroblast
Erythroblast
What happens to the Hb concentration and nucleus as the pro-erythroblast and erythroblast mature?
Hb concentration = increase
Nucleus = smaller and disappears
What leaves the bone marrow and gets into the blood by passing the endothelial walls of bone marrows capillaries?
Mature erythrocytes
What is the name for when their is a high number of reticulocytes in circulation?
Regenerative anemia
What are NOT common in the blood?
Reticulocytes
What cell number in the blood can be used as a measure of the production rate of erythrocytes in an animals?
Reticulocytes
What requires the following:
Iron
Vitamin B12 and folic acid
Erythropoietin
Erythropoiesis
What is the name for an increased number of erythrocytes?
Polycythemia
Where is erythropoietin produced?
Kidney
As erythrocytes age, their membrane become _____ flexible and they are more easily __________ as they pass through the capillaries
Less
Damaged
What is the destruction of old erythrocytes mediated by?
Macrophages
What 3 places are where destruction of erythrocytes take place?
Spleen, liver, bone marrow
What are released from Hb will be recycled for protein synthesis?
Peptides
What will heme groups be converted into that goes into the bile?
Bilirubin
What will be transported to the bone marrow for the formation of new heme groups?
Iron
What is the lifespan of erythrocytes?
90-140 days
What is iron stored as in the liver?
Ferritin
Where is ferritin and bilirubin stored?
Liver
Where is iron for production of erythrocytes stored?
Bone marrow
