Blood Cells And Coagulation Part 1- 2

Question 1

Hb can __________ bind to oxygen without changing the valance

Answer 1

Reversibly

Question 2

How many subunits does hemoglobin consist of?

Answer 2

4

Question 3

Each subunit of hemoglobin contains a ________ peptide chain, and a ____ group that contains _____ on its center

Answer 3

Globular
Heme
Iron

Question 4

What is the formation of blood cells?

Answer 4

Hematopoiesis

Question 5

What is the formation of red blood cells?

Answer 5

Erythropoiesis

Question 6

Where does erythropoiesis occur by the division of stem cells during fetal life?

Answer 6

Liver and spleen

Question 7

Where does erythropoiesis occur by the division of stem cells from brith until adolescence?

Answer 7

Red bone marrow of long bones

Question 8

Where does erythropoiesis occur by the division of stem cells from adolescence onwards?

Answer 8

Red bone marrow of flat bones

Question 9

What is the name of the single cell type in the bone marrow where are all blood cells derived from?

Answer 9

Pluripotent stem cell

Question 10

After some cell division, which 2 cells become predestined into differentiate into erythrocytes?

Answer 10

Pro-erythroblast
Erythroblast

Question 11

What happens to the Hb concentration and nucleus as the pro-erythroblast and erythroblast mature?

Answer 11

Hb concentration = increase
Nucleus = smaller and disappears

Question 12

What leaves the bone marrow and gets into the blood by passing the endothelial walls of bone marrows capillaries?

Answer 12

Mature erythrocytes

Question 13

What is the name for when their is a high number of reticulocytes in circulation?

Answer 13

Regenerative anemia

Question 14

What are NOT common in the blood?

Answer 14

Reticulocytes

Question 15

What cell number in the blood can be used as a measure of the production rate of erythrocytes in an animals?

Answer 15

Reticulocytes

Question 16

What requires the following:
Iron
Vitamin B12 and folic acid
Erythropoietin

Answer 16

Erythropoiesis

Question 17

What is the name for an increased number of erythrocytes?

Answer 17

Polycythemia

Question 18

Where is erythropoietin produced?

Answer 18

Kidney

Question 19

As erythrocytes age, their membrane become _____ flexible and they are more easily __________ as they pass through the capillaries

Answer 19

Less
Damaged

Question 20

What is the destruction of old erythrocytes mediated by?

Answer 20

Macrophages

Question 21

What 3 places are where destruction of erythrocytes take place?

Answer 21

Spleen, liver, bone marrow

Question 22

What are released from Hb will be recycled for protein synthesis?

Answer 22

Peptides

Question 23

What will heme groups be converted into that goes into the bile?

Answer 23

Bilirubin

Question 24

What will be transported to the bone marrow for the formation of new heme groups?

Answer 24

Iron

Question 25

What is the lifespan of erythrocytes?

Answer 25

90-140 days

Question 26

What is iron stored as in the liver?

Answer 26

Ferritin

Question 27

Where is ferritin and bilirubin stored?

Answer 27

Liver

Question 28

Where is iron for production of erythrocytes stored?

Answer 28

Bone marrow