Block 3 Autocoids

Question 1

Oxytocin (prostaglandins)

Answer 1

Uterine smooth muscle contraction

*Do not give via IV due to risk of uterine rupture

Question 2

Misoprostol (prostaglandins)

Answer 2

MOA: PGE1 analog

• prev & rx of NSAID-induced ulcers
• used for male impotency
• medically terminate pregnancy w/ Mifepristone

Question 3

Alprostodil (prostaglandins)

Answer 3

MOA: PGE1 analog

• maint. of DA patency
• used for male impotency

Question 4

Dinopristone (prostaglandins)

Answer 4

MOA: PGE2 analog

• induce uterine sm. mus. cntrxn in labor
• used for cervical effacement (thinning)

Question 5

Latanoprost (prostaglandins)

Answer 5

MOA: PGF2-alpha analog
*topical eye drops for glaucoma
*induces labor
SE: iris brownish discoloration

Question 6

Carboprost (prostaglandins)

Answer 6

MOA: PGF2-alpha analog

*induces labor

Question 7

Eprprostenol (prostanglandins)

Answer 7

MOA: prostacyclin analog

• admin. via infusion pump
• used for pulm. HTN & vasodil

Question 8

Diphenhydramine (H1 blocker - 1st gen)

Answer 8

• comp, reversible H1 blocker

* most common OTC pill used in suicide

Question 9

Dimenhydrinate

Answer 9

H1 blocker - 1st gen

Question 10

Meclizine (H1 blocker - 1st gen)

Answer 10

anti-motion sickness, ok for pregnancy

Question 11

Promethazine

Answer 11

• local anesthetic

* alpha-1 blocking properties

Question 12

Hydroxyzine

Answer 12

highly sedative

Question 13

Chlorpheniramine

Answer 13

H1 blocker - 1st gen

Question 14

Cetrizine

Answer 14

low sedative properties

• very high M-blocking properties: xerostomia, urine ret, vertigo, hypoTN, cycloplegia, bronchodil, constipation
• BBB+
• causes Wt. gain

Question 15

Loratadine, Desloratadine, Fexofenadine (H1 blockers - 2nd gen)

Answer 15

M-blocking properties but *BBB-

used in allergies

Question 16

“tidine”’s (H2 blockers)

Answer 16

(decrease HCL prod)

increase HR & contractility

Question 17

Buspirone (PA @ 5HT1A receptor)

Answer 17

used in GAD (anxiolytic)

*doesn’t alter GABA so has less chances of abuse or dependence

Question 18

Sumatriptan (PA @ 5HT1D receptor)

Answer 18

causes cerebral vasc constrict

• decreases migraine pain
• CI in vasc, heart diseases, and pts susceptible to vasocon

Question 19

Cyproheptadine (ANT @ 5HT2 receptor)

Answer 19

used for carcinoid (inc serotonin)

used for anorexia nervosa (Increased appetite)

Question 20

Octreotide (Somatostatin analog)

Answer 20

Decreases the secretion of 5HT

used for carcinoid

Question 21

Olanzapine (5HT2 antagonist)

Answer 21

new anti-psychotic drugs

Question 22

Ondansetron (5HT3 antagonist)

Answer 22

used for vomiting (cancer-induced)

SE: constipation, bowel impaction, ischemic colitis

Question 23

Cisapride & Tegaserod (5HT4 agonist)

Answer 23

Prokinetics
Increases motility
SE: diarrhea & torsades (vent arrhythmia w/ prolonged QT interval)

Question 24

Ergotamine/Dihydroergotamine (Ergot Alkaloids)

Answer 24

used for acute migraine attacks or prodrome stage

MOA: inc uterine sm ms cntrx & casues vasocon

Question 25

Ergonavine

Answer 25

• administered intramuscularly

* prevents post-partum hemorrhages after placental delivery

Question 26

Methysergide

Answer 26

uses: acute migraine attacks or prodrome stage
SE: fibrosis
CI: pregnancy, vasc, heart diseases