Block 3 Anesthetics

Question 1

Halothane (Inhaled)

Answer 1

MOA: interact with neuronal membrane inhibit ion influx
LOW MAC VALUE
High B/G, met by liver
SE: 3 H’s

Question 2

Isoflurane (Inhaled)

Answer 2

High B/G
SE: bronchocon & inc bronchiolar sensitivity
CI: asthma

Question 3

Desflurane (Inhaled)

Answer 3

Low B/G SE: airway irritation

Question 4

Sevoflurane (Inhaled)

Answer 4

Low B/G, safe in asthma, CI: kidney dysfxn

Question 5

Enflurane (Inhaled)

Answer 5

muscle spasms

Question 6

N2O

Answer 6

MOA: nitrous oxide
does NOT cause sk ms relax 
HIGH MAC value
LOW B/G
"laughing gas"
SE: diffusional hypoxia, can cause abortion in pregnancy

Question 7

Thiopental (IV)

Answer 7

Barbiturate
very lipid soluble
OD: resp & cvs depression
OD Rx: urine alk

Question 8

Midazolam (IV)

Answer 8

Benzo
Causes sk ms relax
OD: resp & cns depression
OD Rx: IV Flumazenil (BZ receptor ant)

Question 9

Fentanyl (IV)

Answer 9

Opioid
has analgesic fx
OD: resp depression, miosis, constipation
OD Rx: Naloxone (Opioid reception ant)

Question 10

Propofol (IV)

Answer 10

“Milk of Amnesia”
anti-emetic fx
rapid onset&recovery
out-pt surgeries

Question 11

Ketamine (IV)

Answer 11

PCP analog
MOA: NMDA ant
only anesthetic to cause CVS stimulation
causes: amnesia, analgesic, cataplexy
decreases pain perception

Question 12

Cocaine, Procaine, Chloroprocaine (Local) (Esters)

Answer 12

MOA: Na+ channel blocker
shorter duration
met by esterase in plasma

Question 13

Lidocaine, Bupivacaine, Mepivacaine (Local) (Amides)

Answer 13

Greater analgesic prop
longer duration
met by amidases in liver

Question 14

Tetrodotoxin

Answer 14

Puffer fish; MOA: blocks ACTivated Na channels

Question 15

Saxitoxin

Answer 15

dinoflagellates in red tide; blocks ACTivated Na channels

Question 16

Ciguatoxin

Answer 16

exotic fish; bind to ACTivated Na channels keeping them open

Question 17

Batrachotoxin

Answer 17

south american frogs; bind to activated Na channels keeping them open