Block 3 Anti-Convulsants

Question 1

Phenytoin

Answer 1

MOA: decrease Na+ influx; inhibits inactivated channels
Uses: All except ABSENCE seizures, anti-arrhythmic
SE: Osteomalacia, Meg Anemia
DI: warfarin tox
SE: Fetal Hydantoin syndrome (cleft lip), switch to phenobarbital, if cant give vit K

Question 2

Carbamazepine

Answer 2

MOA: inhibits Na+ influx
Uses: all except absence, Tic-Dolorex, backup for Bipolar
SE: SIADH (excess adh from post pit)

Question 3

Ethosuximide

Answer 3

MOA: inhibits Ca++ influx in thalamic nucei
Uses: Absence
SE: sedation severe GI distress

Question 4

Valproic Acid

Answer 4

Inhibits Ca++,Na+, GABA transaminases
Uses: ALL Seizures, migraine prophylaxis, backup for bipolar
SE: heptox, pancreatitis,cp450 inhibitor

Question 5

Felbamate & Lamotrigine

Answer 5

MOA: blocks glutamate & sodium channels
F: cause aplastic anemia
L: cause Steven-Johnson syndrome

Question 6

Gabapentin

Answer 6

MOA: GABA analog
Uses: neuropathic pain, painful seizures

Question 7

Intractible Epilepsy

Answer 7

Epileptic surgery needed, temporal lobe resection