Block 3 Anti-Parkinson's

Question 1

L-Dopa & Carbidopa

Answer 1

L: BBB+ acts on CNS
C: prevents peripheral dopamine conversion, BBB-
SE: hypoTN, tachycardia

Question 2

Tolcapone, Entacapone

Answer 2

COMT inhibitors

Question 3

Bromocriptine, Pergolide, Pramepexole, Ropirenole (Dopamine receptor agonists)

Answer 3

Pram: PA
R: PA
uses: hyperprolactinemia, acromegaly

Question 4

Selegeline

Answer 4

MOA: MAO-B inhib

MPTP is drug of abuse, this rx prevents formation of toxic MPP

Question 5

Amantadine

Answer 5

MOA: inc release and dec uptake of dopamine
Uses: parkinsons, influenza A
SE: Livido Reticularis (pale skin and rash)
Purplish mesh work & dilated veins
Edema and Skin mottline

Question 6

Benzotropine, Trihexyphenidyl, Diphenhydramine (M-blockers)

Answer 6

CI: BPH, acute glaucome, urine ret

Question 7

Anti-histamine

Answer 7

used for rigidity and tremors but not bradykinesia