Block 3 Anti-Inflammatory Flashcards
Aspirin
MOA: irreversible COX-I
SE: salicylism, ulcers, impaired gestation, Reye’s syndrome, analgesic nephropathy
CI: lithium tox, warfarin tox,
OD Rx: NaHCO3
Ibuprofen, Naproxen, Diclofenac, Ketorolac, Sulindac, Indomethacin, Piroxicam
MOA: reversible COX-I
Ketorolac: post-op pain
Indomethacin: PDA closure
Diclofenac: Hepatic Toc
Celecoxib & Rofecoxib
MOA: reverisble COX2 inhib
SE: MI risk, renal dysfxn
Uses: anti-inflammatory
Acetaminophen
Only inhibits COX in cns
causes centrilobular heptox
OD Rx: N-Acetyl Cysteine
Hydroxychloroquine
MOA: stabilizes lysosomes & inhibits chemotaxis
SE: hemolysis, cinchonism, retinopathy
Methotrexate
MOA: cytotoxic to lymphocyte
Sulfasalazine
Met into Sulfapyradine & 5-ASA
Sulfapyridine inhibits B-cell fxns
5-ASA inhibits cox
Gold Salts
MOA: suppress phagocytosis & toxic to lymphocytes
Glucocorticoids
MOA: decreases leukotrienes, interleukins, & PAF
anti-inflammatory & immunosuppression
Penicillamine
MOA: suppresses T-cells & inhibits rheumatoid factor
used in chelates & Wilson’s disease
Etanercept
MOA: decreases the effects of TNF-alpha by binding it
*prevents it from illiciting a response
Leflunomide
MOA: dihydro-orotic acid dehydrogenase
arrests lymphocytes in G1 phase
Infliximab
MOA: monoclonal antibody against TNF-alpha
*used for Crohn’s
SE: infections
Anakinra
MOA: IL-1 receptor antagonist
NSAIDs & Colchicine (acute gout rx)
Colchicine: binds to tubulin during M-phase to inhibit micro-tubular polymerization
SE: heartburn
