Block 3 Anti-Anxiety & Sedative Hypnotics

Question 1

Baclofen (GABA-B agonist)

Answer 1

sk ms relaxant, (increases K+ efflux)

Question 2

Flunitrazepam

Answer 2

date rape drug (causes anterograde amnesia)

Question 3

Diazepam

Answer 3

longer D.O.A, active for 8 hours

Question 4

OTL: Oxazepam, Temazepam, Lorazepam

Answer 4

(Off the liver), O&T: shorter durations (insomnia usage)

L: longer DOA, (anxiety & seizure usage), and Alcohol withdrawal seizures

Question 5

Midazolam

Answer 5

IV anesthetic

Question 6

Clonazepam

Answer 6

muscle relaxation w/ less sedation

Question 7

Triazolam

Answer 7

decreasing sleep latency (insomnia)

withdrawal -> rebound insomnia

Question 8

Alprazolam

Answer 8

MC used for anxiety, panic disorders, phobias

Question 9

Diazepam

Answer 9

used for status epilepticus, and alcohol withdrawal seizures

Question 10

Flumazenil

Answer 10

MOA: BZ receptor antagonist

*given via IV to reverse benzo OD

Question 11

Withdrawal symptoms: rebound: anxiety, agitation, insomnia, seizures (more in barbs & alchy), confusion

Answer 11

Rx: IV diazepam or lorazepam

Question 12

Phenobarbital

Answer 12

Longest DOA, safe for pregnancy seizures, CP450 inducer

Question 13

Thiopental

Answer 13

Shortest DOA, used as an IV anesthetic, status epilepticus, febrile seizures in children

Question 14

Overdose

Answer 14

Alkalization of urine

Question 15

Zolpidem/Zoleplon

Answer 15

MOA: BZ1 receptor agonist
*used for insomnia
OD Rx: IV Flumazenil