Block 3 Anti-Depressants

Question 1

Phenelzine, Isocarboxid, Trancylpromine (MAO-I)

Answer 1

2nd line rx, DI: tyramine and serotonin syndrome

Question 2

(Imipramine, Desipramines, Clomipramine), (Amitriptiline, Nortriptiline), (Amoxapine)
SE: Triad of C’s
Rx: urine alk

Answer 2

C: 2nd rx for OCD, 1st for SSRI, SE: GI Distress
Ami: neuropathic pain
I: nocturnal enuresis
Amox: anti-dopaminergic fx, se: eps & hyperprolactinemia
DI: TCA + SSRI = Serotonin Syndrome

Question 3

Fluvoxamine, Fluoxetene/Paroxetene, Citolopram, Sertraline (SSRI)

Answer 3

MOA: inhibits 5HT reuptake

OCD 1st line, causes Wt. loss, delays orgasm, bruxism

Question 4

Venlafaxine, Duloxetine

SNRI

Answer 4

MOA: inhibit reuptake of NE & 5HT
D: neuropathic pain

Question 5

Trazadone, Nefazadone, Mirtazapine, Bupropion

Answer 5

T&N: serotonin-2 ant & reuptake inhib, SE: priapism
M: a-2 ant (inc NE)
B: inhib reuptake of dopamine

Question 6

Smoking cessation

Answer 6

Bupropion: se: seizures and wt loss
Nicotine patches: CI if heart problems
Varenicline: PA of nicotinic receptors, CI in depression

Question 7

Lithium

Answer 7

MOA: modulates cAMP
SE: Nephrogenic DI, Rx: stop lithium & start Amiloride
CI: pregnancy, Epstein’s anomaly