Block 11 Flashcards
psychological complaints are best treated with __
therapy
brain disorders are best treated by __
drugs
schizophrenia is characterized by disturbances in these three things
communication, perception, thought
True/False: schizophrenia is a mood/affective disorder
false
schizophrenia produces “false” realities that conflict with cognition, indicating ___ abnormalities
sensory
sensory input attributed to a different modality
synesthesia
__ symptoms in schizophrenia include the presence of distinctive behaviors
florid
disorganized thinking, paranoia, delusions of grandeur, and bizarre ideations are all __ symptoms of schizophrenia
florid
__ symptoms in schizophrenia include the absence of normal and social behavior
negative
neglect of personal hygiene, odd behavior and ideas, social isolation, withdrawal, and catatonia are all __ symptoms of schizophrenia
negative
__ symptoms often precede __ symptoms (schizophrenia)
negative; florid
medications reduce the __ symptoms of schizophrenia, leave __ symptoms unaffected
florid; negative
What is the most common medication type for schizophrenia?
atypical antipsychotics
atypical antipsychotics are classified as a __
neuroleptic
examples of atypical antipsychotics used for schizophrenia
thorazine, haldol, clozapine
atypical antipsychotics work by blocking _
dopamine
atypical antipsychotics have a __ effect on non-schizophrenics
sedative
In neuroleptic drugs, there is a correlation between clinical efficacy and how well the drugs bind __
dopamine receptors
the underlying deficiency in schizophrenia is too much __ (the __ hypothesis)
dopamine
the DA:NE ratio in the __ is higher in schizophrenics
thalamus
more dopamine in the thalamus is consistent with a __ disorder
sensory processing
schizophrenics have larger ___ ___ than low-risk normals, therefore creating a loss in other brain tissues and cortexes
cerebral ventricles
Denmark studies of birthrate of schizophrenics to mothers who developed the flu during their second trimester shows that there is a ___ ___ of stress on mom and fetus
gestational impact
in an __ illness, person perceives reality (sensory stimuli) normally, but feelings or affect about that reality may be distorted
affective illness
symptoms of __ include accelerated thought process, euphoria, exaggerated sexual or physical appetite, illusions of invincibility, and grandiose ambitions
mania
symptoms of __ include suicidal thoughts, ahedonia, psychomotor retardation, expressions of helplessness, hopelessness, and worthlessness, and sleep disturbances
depression
in __ illness, depression with no mania alternates with normal periods
unipolar
in __ illness, brief periods of mania oscillate with brief periods of depression and prolonged periods of normalcy
bipolar
when traumatic events lead to short-term depression, this is called
reactive depression
The __ Hypothesis suggests that an abnormality in monaminergic transmission underlies almost all mental illnesses
monoamine
depression is caused by too little brain ___
catecholamine
the catecholamines involved in depression are __ and __
DA and NE
First drugs for depression were designed/used to increase extracellular __
catecholamines
First drugs for depression were __
Monoamine Oxidase Inhibitors (MAOIs)
MAOIs block the breakdown of __
catecholamines
amphetamines have the same effect as these antidepressant drugs
MAOIs
side effects of MAOIs
hypertension and accelerated heart rate
drugs developed as an effort to find a drug affecting only receptor sites central to depression (alters receptor binding)
tricyclic antidepressants
tricyclics block __ re-uptake and increase extracellular levels
monoamine
tricyclics closely resemble what kind of drug?
neuroleptics
tricyclics have less cardiovascular effects than MAOIs because they work in the ___
CNS
SSRIs are __ antidepressants
atypical
SSRIs selectively block __ reuptake pump
serotonin
symptoms of __ include intense dread and generalized avoidance
anxiety
medication for anxiety treatment; acts as a tranquilizer; part of the benzodiazepine family
anxiolytics
most heavily prescribed medications with major addictive potential; allosteric modifier at GABA receptors that increases inhibitory potency of GABA
benzodiazapines