Bipolar Disorders Flashcards
True or False: Bipolar disorder is among the most heritable of disorders.
True
State the 4 brain structures implicated in bipolar disorders and their level of activity.
- Amygdala (high)
- Subgenual anterior cingulate (high)
- Dorsolateral prefrontal cortex (low)
- Hippocampus (low)
What neurobiological factor suggests that people with bipolar disorder may be neurobiologically hypersensitive to rewarding cues in the environment?
Overly active striatum
What is the implication of having abnormal white matter in the prefrontal cortex, in relation to bipolar disorder?
- Prefrontal cortex has difficulty communicating with and exerting control over other areas.
- Emotions become disorganized, and behavior becomes extreme.
What neurobiological factor is seen in people with bipolar disorder and not in people with major depression?
Cellular membrane deficits
What brain lobe shows elevated activity in bipolar spectrum patients, which predicts the onset of bipolar I disorder?
Left frontal lobe
What neurotransmitter receptors are overly sensitive in individuals with bipoolar disorder?
Dopamine receptors
What neurotransmitter receptors show low sensitivity in individuals with bipolar disorder?
Serotonin receptors
Apart from high sensitivity of dopamine and low sensitivity of serotonin receptors, state 1 other neurobiological factor in bipolar disorder with regard to neurotransmitter activity.
Abnormally high protein kinase C activity
State at least 1 neurobiological factor in bipolar disorder with regard to the neuroendocrine system.
- Dysregulated cortisol
- Overactive behavioral approach system
State at least 1 psychological contribution to the development of bipolar disorder.
- Neuroticism
- Negative cognitive style
- Reward sensitivity
What characterizes the negative cognitive style seen in individuals with bipolar disorder?
- Ambitious striving for goals
- Perfectionism
- Self-criticism
State at least 2 social contributions to the development of bipolar disorder.
- Stressful events
- Lack of social support
- High sensitivity to punishment
Bipolar disorder specifier that does not respond well to standard treatments and is accompanied by at least 5 manic/hypomanic or depressive episodes within 1 year
Rapid cycling specifier
Pattern of rapid cycling that only lasts for days to weeks
Ultra-rapid cycling