Biostats/Ethics Flashcards
good screening test
sensitive tests (negative results are reliable)
PPV increases as
prevalence increases
negative predictive value is most useful when
prevalence is low
null hypothesis
by chance
goal of research
reject the null hypothesis
the chance the null hypothesis was rejected due to error
p value
type 1 error
p value - rejected the null hypothesis in error
type 2 error
accepted the null hypothesis in error (deemed study not significant even though it was)
internal validity reflects
accuracy
external validity reflects
generalizability
whether a test actually measures what it is intended to measure
validity
consistency or repeatability of scores
reliability
absolute risk reduction
rate in untreated group - rate in treated group
number needed to treat
1/rate in untreated - rate in treated (1/ARR)
number of newly diagnosed cases in a period of time
incidence
total number of cases that exist in a population
prevalence
strongest to weakest studies
randomized controlled, cohort, case-control, cross-sectional, case study
comparing a group with an exposure to a group without an exposure
cohort study
limitations of cohort study
requires large sample size, expensive and requires a long time period
check for risk factors in a patient with the disease and a patient without
case-control study
study that is useful with small sample sizes, long latency periods or rare outcomes
case-control studies
observational study looking for associations between two factors at one point in time
cross-sectional study
conditions that growth hormone is FDA approved for
prader-willi, Turner syndrome and chronic renal insufficiency
near miss
an error that does not cause harm