Biology - Chapter 11.7: Endocrine System Flashcards
Three Types of Hormones
1) Peptide hormones
2) Steroid hormones
3) Amino-acid derived hormone
Peptide Hormone Synthesis
- rough ER
- made of amino acids connected by peptide bonds
Peptide Hormone Action
- Indirect stimulation
- Bind to cell surface receptors
- via secondary messengers or ligand-gated ion channels
GPCRs
- G-protein coupled receptors
- cell surface receptors that initiate a secondary messenger response
- dissociates into subunits after activation (alpha beta gamma)
RTKs
- Receptor tyrosine kinases
- cell surface receptors that dimerizes and initiates a second messenger response after binding to peptide hormone
- intracellular domains of RTKs cross-phosphorylate and initiate second messenger signaling within the cell
Second messenger system allows for…
… quick and immediate physiological changes
Steroid Hormone Synthesis
- smooth ER
- made up of fused 4-ring structure
Steroid Hormone Examples
- All hormones produced by adrenal cortex (glucocorticoids, mineralocorticoids, androgenic steroids)
- All hormones produced by reproductive organs
Steroid Hormone Action
- carried through blood-stream via protein carrier
- freely crosses cell membrane
- binds to receptors in cytoplasm or nucleus to form molecule-receptor complex
- these complexes bind to DNA and influence gene transcription (direct stimulation)
Amino-acid derived hormones
can have properties that are similar to both peptide hormones and steroid hormones
Amino-acid derived hormones synthesis
- rough ER and cytosol
- mainly derived from tyrosine
Amino-acid derived hormones examples
- All hormones produced in adrenal medulla (epinephrine, norepinephrine)
- T3 and T4
Posterior pituitary hormones
1) ADH: decreases urination by increasing water retention
2) Oxytocin: uterine contractions, lactation
Anterior pituitary hormones
1) GnRH (gonadotropin-releasing): causes release of LH and FSH
2) TRH (thyrotropin-releasing): causes release of TSH
3) CRH (corticotropin-releasing): causes release of ACTH
4) GRH: causes release of GH (growth hormone)
Hypothalamic-inhibiting hormones
-Released by hypothalamus to inhibit release of other hormones by anterior pituitary
Tropic hormones
-Target other endocrine glands for further hormone release
FSH
- tropic hormone released by anterior pituitary
- follice growth and sperm maturation
LH
- tropic hormone released by anterior pituitary
- ovulation, corpus luteum formation and testosterone production