Biol 445 Test 1

Question 1

let-23

Answer 1

EGFR homologue
Vul mutation (recessive loss of function)
Expressed in VPCs

Question 2

lin-3

Answer 2

EGF homologue
Vul mutation (recessive loss of function)
Expressed in ACs

Question 3

lin-15

Answer 3

Negative regulator of vulval induction
Muv mutation (recessive loss of function)
Regulates localization of let-23 receptor

Question 4

let-60

Answer 4

Ras homologue
Muv mutation (dominant gain of function)

Question 5

sem-5

Answer 5

GRB2 homologue

Positive regulator

Question 6

lin-45

Answer 6

Raf homologue

Question 7

Having an abnormal amount of chromosomes and abnormal translocations

Answer 7

Aneuploidy

Question 8

5 properties of cancer cells

Answer 8

Immortalized
Do not form differentiated tissues
No contact inhibition
Invasive
Escape apoptosis