Biol 445 student presentations Flashcards
TGF-beta receptor 1/ALK 5 (types of cancer/disease cell function tumor suppressor/oncogene?)
Pancreatic, gastric, and lung cancers
Induces epithelial to mesenchymal transition (EMT)
Tumor suppressor in early stages (anti-growth) and oncogene later
Notch1 (types of cancer/disease cell function tumor suppressor/oncogene?)
T-ALL
Cellular “switch” promoting differentiation
Oncogene
Smoothened (types of cancer/disease cell function tumor suppressor/oncogene?)
Basal cell carcinoma
Regulation of cell differentiation and organ formation during embryonic development
Oncogene
BRCA2 (types of cancer/disease cell function tumor suppressor/oncogene?)
Breast cancer
Homologous recombination protein that repairs DNA breaks; G2 checkpoint regulator
Tumor suppressor
WT1 (Wilms tumor 1) (types of cancer/disease cell function tumor suppressor/oncogene?)
Childhood renal cancer
Zinc-finger TF mediating epithelial to mesenchymal transition (EMT)
Tumor suppressor
PTEN (types of cancer/disease cell function tumor suppressor/oncogene?)
Cowden syndrome
lipid phosphatase that opposes PI3K, controls growth
Tumor suppressor
Bcl-2 (types of cancer/disease cell function tumor suppressor/oncogene?)
Lymphoma
Protein embedded in mitochondrial membrane that prevents apoptosis
Oncogene
NF1 (types of cancer/disease cell function tumor suppressor/oncogene?)
Neurofibromatosis
GAP for Ras
Tumor suppressor
FANCD2 (types of cancer/disease cell function tumor suppressor/oncogene?)
Fanconi’s anemia; sometimes leads to AML Cross-link repair and S phase arrest protein in the nucleus DNA repair/tumor suppressor
MLH1 (types of cancer/disease cell function tumor suppressor/oncogene?)
Hereditary non-polyposis cancer; endometrial cancer Recruits mismatch repair proteins to site of mismatch DNA repair; mutations increase propensity to acquire other mutations (no fit in classical definitions of tumor suppressor/oncogene)
BMP receptor 1A (types of cancer/disease cell function tumor suppressor/oncogene?)
Juvenille polyposis/ colon cancer A RTK ser/thr kinase Tumor suppressor
BRCA1 (types of cancer/disease cell function tumor suppressor/oncogene?)
Breast cancer
Forms complexes to repair double-stranded DNA breaks
DNA repair/tumor suppressor
NF2/Merlin (types of cancer/disease cell function tumor suppressor/oncogene?)
Schwannomas/meningiomas
Membrane-organizing protein that links actin cytoskeleton to plasma membrane; intercepts mitogenic signals
Tumor suppressor
Telomerase (types of cancer/disease cell function tumor suppressor/oncogene?)
Many cancers Elongates telomeres; not found in normal cells but is found in most cancer cells Oncogene (?)
Myc (types of cancer/disease cell function tumor suppressor/oncogene?)
Lymphoma/osteosarcoma
A transcription factor leading to unregulated gene expression
Oncogene
VHL (types of cancer/disease cell function tumor suppressor/oncogene?)
ccRCC (clear cell renal cell carcinoma); Von Hippel Lindau syndrome
Recruits other proteins to form a ubiqulase complex
Tumor suppressor
Patched (types of cancer/disease cell function tumor suppressor/oncogene?)
Basal cell carcinoma Small molecule modulator; Hedgehog receptor Tumor suppressor
PDGFR beta (types of cancer/disease cell function tumor suppressor/oncogene?)
CMML RTK that phosphorylates cell proliferation pathways (like Ras) Oncogene
p57 (types of cancer/disease cell function tumor suppressor/oncogene?)
Beckwith Weidemann Syndrome
Kinase inhibitor; arrests cells in G1
Tumor suppressor
Bloom helicase (types of cancer/disease cell function tumor suppressor/oncogene?)
Bloom syndrome ATP-dependent helicase with broad spectrum of functions including telomere replication and DNA damage repair Tumor suppressor
c-kit (types of cancer/disease cell function tumor suppressor/oncogene?)
GIST
Receptor tyrosine kinase
Oncogene
LKB1/STK (types of cancer/disease cell function tumor suppressor/oncogene?)
Peutz-Jegher’s syndrome; many other cancers ser/thr kinase that activates AMPK cascade (cellular energy homeostasis) Tumor suppressor
HOX A9 (types of cancer/disease cell function tumor suppressor/oncogene?)
AML
Transcription factor that prevents differentiation and promotes proliferation
Oncogene
TGF-beta receptor 2 (types of cancer/disease cell function tumor suppressor/oncogene?)
Gastric, colon, pancreatic cancer
ser/thr kinase, forms heterotrimeric complex with type 1 receptors and propogates signals that do a bunch of stuff
Starts as tumor suppressor; becomes tumor promoter