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Spring 2013 > Biol 445 student presentations > Flashcards

Biol 445 student presentations Flashcards

1
Q

TGF-beta receptor 1/ALK 5 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Pancreatic, gastric, and lung cancers

Induces epithelial to mesenchymal transition (EMT)

Tumor suppressor in early stages (anti-growth) and oncogene later

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2
Q

Notch1 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

T-ALL

Cellular “switch” promoting differentiation

Oncogene

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3
Q

Smoothened (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Basal cell carcinoma

Regulation of cell differentiation and organ formation during embryonic development

Oncogene

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4
Q

BRCA2 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Breast cancer

Homologous recombination protein that repairs DNA breaks; G2 checkpoint regulator

Tumor suppressor

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5
Q

WT1 (Wilms tumor 1) (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Childhood renal cancer

Zinc-finger TF mediating epithelial to mesenchymal transition (EMT)

Tumor suppressor

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6
Q

PTEN (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Cowden syndrome

lipid phosphatase that opposes PI3K, controls growth

Tumor suppressor

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7
Q

Bcl-2 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Lymphoma

Protein embedded in mitochondrial membrane that prevents apoptosis

Oncogene

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8
Q

NF1 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Neurofibromatosis

GAP for Ras

Tumor suppressor

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9
Q

FANCD2 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Fanconi’s anemia; sometimes leads to AML Cross-link repair and S phase arrest protein in the nucleus DNA repair/tumor suppressor

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10
Q

MLH1 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Hereditary non-polyposis cancer; endometrial cancer Recruits mismatch repair proteins to site of mismatch DNA repair; mutations increase propensity to acquire other mutations (no fit in classical definitions of tumor suppressor/oncogene)

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11
Q

BMP receptor 1A (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Juvenille polyposis/ colon cancer A RTK ser/thr kinase Tumor suppressor

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12
Q

BRCA1 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Breast cancer

Forms complexes to repair double-stranded DNA breaks

DNA repair/tumor suppressor

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13
Q

NF2/Merlin (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Schwannomas/meningiomas

Membrane-organizing protein that links actin cytoskeleton to plasma membrane; intercepts mitogenic signals

Tumor suppressor

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14
Q

Telomerase (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Many cancers Elongates telomeres; not found in normal cells but is found in most cancer cells Oncogene (?)

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15
Q

Myc (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Lymphoma/osteosarcoma

A transcription factor leading to unregulated gene expression

Oncogene

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16
Q

VHL (types of cancer/disease cell function tumor suppressor/oncogene?)

A

ccRCC (clear cell renal cell carcinoma); Von Hippel Lindau syndrome

Recruits other proteins to form a ubiqulase complex

Tumor suppressor

17
Q

Patched (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Basal cell carcinoma Small molecule modulator; Hedgehog receptor Tumor suppressor

18
Q

PDGFR beta (types of cancer/disease cell function tumor suppressor/oncogene?)

A

CMML RTK that phosphorylates cell proliferation pathways (like Ras) Oncogene

19
Q

p57 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Beckwith Weidemann Syndrome

Kinase inhibitor; arrests cells in G1

Tumor suppressor

20
Q

Bloom helicase (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Bloom syndrome ATP-dependent helicase with broad spectrum of functions including telomere replication and DNA damage repair Tumor suppressor

21
Q

c-kit (types of cancer/disease cell function tumor suppressor/oncogene?)

A

GIST

Receptor tyrosine kinase

Oncogene

22
Q

LKB1/STK (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Peutz-Jegher’s syndrome; many other cancers ser/thr kinase that activates AMPK cascade (cellular energy homeostasis) Tumor suppressor

23
Q

HOX A9 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

AML

Transcription factor that prevents differentiation and promotes proliferation

Oncogene

24
Q

TGF-beta receptor 2 (types of cancer/disease cell function tumor suppressor/oncogene?)

A

Gastric, colon, pancreatic cancer

ser/thr kinase, forms heterotrimeric complex with type 1 receptors and propogates signals that do a bunch of stuff

Starts as tumor suppressor; becomes tumor promoter

Spring 2013 (31 decks)

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