bio E malberg et al

Question 1

malberg et all

Answer 1

the rats and antidepressants

Question 2

aim

Answer 2

to inv the possibility that antidepressants would increase nerugenesis in rats.

Question 3

participants and RM

Answer 3

rats
true experiment

Question 4

procedure

Answer 4

1) deprived rats of food and water to create stress
2) divided into exp and control
3) injected antidepressants (monoamine oxidase inhibitor and SSRI)
4) electroconvulsive shock
5) measured by the brdU - which is an analog to see which cells are increasing. # of cells.

Question 5

results

Answer 5

rats w antidepressants and electroconvulsive shock had increased neurogenesis - more cells were produced (found by the brdU analog).
increased number of cells in hippoC

Question 6

this is because

Answer 6

the anti depressants inhibited the serotonin reuptake channel in the hippocampus allowing for a prolonged release and effect of the chemical, which then allowed new cells to be made and new connections to be formed.
the shock alerted the rats’ brain chemistry and increased the efficiency of the new neurons formed.

basically
antiD reduced the hippoC cell death

Question 7

this shows that

Answer 7

antidepressants are successful in treating depression by increasing the neurogenesis.

Question 8

which implies that the neurogenesis theory

Answer 8

could explain why some treatments are effective in reducing depressive symptoms, though more research is needed to confirm whether these effects occur similarly in humans.
and that there can be an increase or decrease in the amount of neurons formed.

Question 9

eval:

Answer 9

-:rats not applicable to humans
-: low ecological validity
-: doesn’t explain gender diffs
-: doesn’t explain cog snd sociocultural factors
-: lack of support
-: hard to replicate
+: high internal validitiy
+: low change of DC
+: strong evidence for theory
+: humans have same genetic makeup as rats so.