Benign Lesions in the Liver Flashcards

1
Q

Solid liver lesions in older patients are more likely to be what?

A

Malignant with metastases more common than primary liver cancer in the absence of liver disease

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2
Q

WHat are solid liver lesions in patients with chronic liver disease more likely to represent?

A

Primary Liver Cancer rather than metastases or benign tumour

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3
Q

What is the most common solid liver tumour in non cirrhotic patients

A

Hemangioma (benign)

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4
Q

Name 4 benign liver tumours

A

Hemangioma
Focal nodular hyperplasia
Adenoma
Liver cysts

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5
Q

Name the 2 main types of malignant tumours

A

Primary liver cancers

Metastases

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6
Q

What are the 2 types of Primary liver cancers

A

Hepatocellular carcinoma

Cholangiocarcinoma

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7
Q

What is the commonest liver tumour

A

Hemangioma

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8
Q

Describe a hemangioma

A

A vascular tumour
Usually single and small
Well demarcated capsule
Usually asymptomatic

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9
Q

How do we diagnose a Hemangioma

A

Ultrasound is key
CT
MRI

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10
Q

What is the treatment for hemangioma

A

No treatment

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11
Q

Describe a focal nodular hyperplasia

A

enign nodule formation of normal liver tissue

congenital anomaly

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12
Q

What is the classic appearance of a focal nodular hyperplasia

A

A central scar through the middle of the mass

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13
Q

Who is more likely to have a focal nodular hyperplasia

A

Young and middle aged women

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14
Q

What type of response is a focal nodular hyperplasia?

A

A hyperplastic response to abnormal arterial flow

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15
Q

How can we diagnose a focal nodular hyperplasia

A

Ultrasound
CT
MRI
Fine needle aspiration

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16
Q

What is the treatment for Focal nodular hyperplasia

A

No treatment

No change is required for pregnancy or hormones

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17
Q

What is a hepatic adenoma

A

Benign neoplasm composed of normal hepatocytes with no portal tract, central veins or bile ducts

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18
Q

Who is more likely to get hepatic adenomas?

A

Women

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19
Q

What are hepatic adenomas associated with

A

The contraceptive hormones - mostly oestrogen

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20
Q

What are the symptoms of hepatic adenoma

A

Usually asymptomatic but may have RUQ pain

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21
Q

How might hepatic adenomas present

A

Rupture, haemorrhage or malignant transformation

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22
Q

Where are hepatic adenomas most commonly found

A

In the right lobe in young women

23
Q

How can regression of hepatic adenomas occur

A

If the oral contraceptive is discontinued

24
Q

How can we diagnose hepatic adenoma

A

US
CT
MRI
FNA

25
Q

What is the treatment for hepatic adenomas

A

Stop the hormones and observe every 6 months for 2 years

If there is no regression then surgical incision may be appropriate

26
Q

What liver structures do adenomas contain

A

Purely hepatocyte tumours

27
Q

What liver structures do focal nodular hyperplasias contain

A

All of the liver ultrastructure - RES and bile ductules

28
Q

What type of benign tumour imay bleed

A

Adenoma

29
Q

What type of benign tumour has the risk of developing into a malignant tumour

A

Adenoma

30
Q

How can you describe both adenomas and focal nodular hyperplasia

A

Hypervascular

31
Q

What is a simple cyst

A

A liquid collection lined by an epithelium

32
Q

What do simple cysts look like on US

A

Black holes

33
Q

How common are simple cysts in the liver

A

2nd most common to hemangiomes

34
Q

When would we consider surgical intervention in a simple cyst

A

If the patient was symptomatic

35
Q

What is the cause of hydatid cysts

A

Sheep born parasite

36
Q

What can hydatid cysts erode into?

A

The IVC

37
Q

What is the treatment of a hydatid cyst

A

Marsupialisation or resection

Albendazole (also used for tapeworms)

38
Q

What is polycystic liver disease a result of

A

Embryonic ductal plate malformation of the intrahepatic biliary tree

39
Q

What are the 3 types of polycystic liver disease

A

Von Meyenburg complexes
Polycystic liver disease
Autosomal dominant polycystic kidney disease

40
Q

What is the most common form of PLD

A

Autosomal recessive

41
Q

What are Von Meyenburg complexes

A

Benign cystic nodules throughout the liver

42
Q

When do Von Meyenburg complexes occur

A

During liver development

43
Q

What do the symptoms of PCLD depend on

A

The size of the cysts

44
Q

What is the main What does autosomal dominant polycystic kidney disease result in

A

Renal failure

45
Q

What is the main method of managing polycystic liver disease

A

Conservative treatment

46
Q

What drug is used in PLD for symptom relief and liver volume reduction

A

Somatostatin

47
Q

What are the 3 common symptoms of a liver abscess

A

high fever
Leukocytosis
Abdominal Pain

48
Q

Who tends to appear more unwell a patient with a liver abscess or a patient with metastasis?

A

Liver abscess

49
Q

What is the common history of a patient with liver abscess

A
Abdominal or biliary infection
Dental procedure (rare)
50
Q

What is the treatment for a liver abscess treatment

A

Initial broad spectrum antibiotics

Aspiration/ drainage

51
Q

Why do we do an ECHO on patients with a liver abscess

A

To rule out bacterial endocarditis

52
Q

What do we do for a patient if there is no clinical improvement?

A

Open drainage and resection

53
Q

What is the minimum number of weeks of atibiotic therapy for a liver abscess patient

A

4 weeks