Basal Ganglia and Cerebellum Flashcards

1
Q

What is found directly above the midbrain, posterior to the forebrain and between the cerebral hemispheres?

What makes up this named structure?

A

Diencephalon

  • thalamus, epithalamus, hypothalamus, subthalamus
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2
Q

The diencephalon is said to form the walls of ______

A

third ventricle

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3
Q

Injury to the basal ganglia and the cerebellum results in _______

A

incoordination of movements

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4
Q

Name the lobes of the cerebellum.

A
  • anterior lobe
  • posterior lobe
  • flocculonodular lobe
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5
Q

What is the cerebellum responsible for?

A
  1. Posture
  2. Balance
  3. Coordination of Movements
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6
Q

What is the exact location of the cerebellum?

A
  • inferior to the Occipital lobe and temporal lobes
  • within the posterior cranial fossa
  • tentorium cerebelli seperates the cerebellum from the lobes
  • falx cerebelli separates the cerebellar hemispheres
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7
Q

How is the cerebellum attached to the brainstem?

A

via 3 stalks

(called the peduncles) —middle cerebellar, inferior cerebellar, superior cerebellar

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8
Q

What is the central portion of the cerebellum termed as?

And on either sides of the vermis?

A

the vermis

—the hemispheres

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9
Q

What do the cerebellar peduncles carry?

A
  • the MIDDLE and the INFERIOR peduncles carry info. IN

- Superior peduncle carries info. OUT

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10
Q

Name the afferents that arrive at the cerebellum.

A
  • vestibular apparatus via Vestibular nuclei
  • Spinal cord (pressure and somatic proprioceptors)
  • cerebral cortex (via the pons)
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11
Q

Name the 3 layers, the cerebellar cortex is divided into.

A
  1. Molecular Layer (outer)
  2. Purkinje Cell layer (middle)
  3. Granule cell layer (inner)
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12
Q

What are the deep grey matter in the cerebellum?

A
  • deep cerebellar nuclei
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13
Q

What do the afferents mainly project to in the cerebellum?

A
  • the granule cell layer (INNER)
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14
Q

Which is the only layer, from which the cerebellum sends output projections?

A
  • from the axons of the Purkinje cells

> synapse with deep cerebellar nuclei; allowing thr coordination of all motor tracts

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15
Q

Where do the efferents axons of the cerebellar nuclei synapse at?

A
  • the thalamus (after crossing over the midline)
  • and red nucleus
    > thalamus sends fibres to the MOTOR cortex
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16
Q

What side of bodily coordination is the cerebellum in charge of?

A
  • the hemispheres influence the IPSILATERAL side of body

- —-lesions> ipsilateral signs

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17
Q

What kind of cells are purkinje cells?

A
  • inhibitory neurones
  • release GABA
  • —-therefore helps MODIFY movement
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18
Q

What occurs with bilateral cerebellar dysfxn?

A
  • slowed, slurred speech (DYSARTHRIA)
  • b/l incoordination of arms
  • wide based gait, staggering
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19
Q

When is bilateral cerebellar dysfxn seen?

A
  • with Acute Alcohol exposure
20
Q

What is seen with unilateral cerebellar lesion?

A
  • disturbance of coordination in LIMBS
  • intention tremor
  • unsteady gait
  • —in the absence of weakness and sensory loss
21
Q

What occurs with midline cerebellar lesion?

A
  • disturbance of POSTURAL control
  • pt will tend to FALL over when standing/ sitting
  • preserved limb coordination
22
Q

Why does a midline lesion present with postural problems?

A
  • as the midline portion of the cerebellum carries the spinocerebellar tract
23
Q

Name the 3 deep nuclei of the cerebellum

A
  1. Dentate
  2. Interposed
  3. Fastigial
24
Q

Which deep nuclei is the MOST lateral and where does it project to?

A

Dentate
—-projects to the CONTRALATERAL VA, VL nuclei of the thalamus (same ones basal ganglia coordinates with) —–HELPS modify movements

25
What is the basal ganglia responsible for?
1. to facilitate PURPOSEFUL movements 2. inhibit UNWANTED movements 3. Role in MUSCLE TONE and POSTURE
26
What makes up the basal ganglia?
1. Caudate nucleus 2. Putamen 3. Globus Pallidus 4. Subthalamic nucleus 5. Substantia Nigra
27
Which components of the basal ganglia ,make up the corpus striatum?
Caudate nucleus Putamen Globus Pallidus
28
What makes up the striatum?
- caudate and putamen
29
What makes up the Lenticular nucleus?
- putamen and globus pallidus
30
SO midline lesions of the cerebellum causes imbalance where _____
in the trunk (truncal ataxia)
31
Lateral cerebellar lesions will present with signs in the _______.
extremities - intention tremor - ---tend to fall to the affected side
32
Where is the substantia nigra located ?
in the MIDBRAIN
33
When does pallor of the substantia nigra occur? And why?
- with PARKINSON'S disease | - d.t degeneration of the DOPAMINERGIC neurones of the substantia nigra
34
How does the basal ganglia help work with Motor cortex to enhance normal movement?
- either ramps up and enhances the movement - through the DIRECT pathway - INDIRECT pathway: inhibits outflow of thalamus
35
What occurs with unilateral lesions of the basal ganglia?
- affects the contralateral side
36
What are the symptoms of basal ganglia lesion ?
- changes in MUSCLE tone | - dyskinesias (tremor/ chorea/ myoclonus)
37
Lesions to the flocculonodular presents in what way?
- nystagmus - vertigo (d.t its connxns to the vestibular nuclei)
38
What does a positive romberg's test mean?
- falling over with eyes closed | = SENSORY ATAXIA (loss of proprioception)
39
With cerebellar ataxia, what is the romberg's test like?
- pt falling over even with their EYES OPEN
40
What the main location of Parkinson's and Huntingtons disease?
- basal ganglia
41
What occurs pathologically with huntington's disease?
- progressive degen. of basal ganglia and cerebral cortex.
42
What are other symptoms of Cerebllar disease?
1. scanning speech 2. Hypotonia (loss of muscle resistance from passive movement) 3. dysynergia 4. Nystagmus 5. N.V 6. Vertigo
43
What is dysnergia? Give examples.
- loss of coorrdinated activity 1. DYsmetria 2. Dysdiadochokinesia 3. INtention tremor
44
What is the blood supply to the cerebellum?
- superior cerebellar - Anterior inferior Cerebellar artery - Posterior INferior cerebellar artery (SCA/ AICA/PICA)
45
Name 2 cerebellar conditions that are autosomal recessive.
1. Ataxia Telangiectasia | 2. Friedreich's Ataxia
46
Which hereditary cerebellar condition is at HIGH RISK of CANCER?
- Ataxia telangiectasia --also have poor immune system (freq. infections