B8-084 HPV Flashcards
area where squamous epithelium of ectocervix meets the columnar epithelium of endocervix
squamocolumnar junction
the viral oncogene of HPV inactivates what tumor suppressor gene?
p53
which HPV subtypes account for 90% of genital warts? [2]
(condylomata acuminata)
6, 11
routine HPV vaccination is recommended to what target age group?
11-12 years
E6 inhibits
p53
(loss of tumor suppression)
E7 inhibits
pRb
(allows cell cycle progression)
does removing genital warts eradicate the HPV infection?
no
most commonly used treatment for genital warts due to HPV
imiquimod
strongest risk factors for high-grade dysplasia due to HPV
HPV strain (16, 18)
persistent infection (older age)
(co factors: smoking, multiparity, long term contraception, immunosuppression)
strains of HPV most likely to cause cervical dysplasia?
16, 18
(also anal cancer)
the timeline from cervical dysplasia to cancer is about […] years
10-30
CIN 1 is […] grade
low
CIN 3 is […] grade
high
vaccines are a […] prevention strategy
primary
pap smear is a […] prevention stategy
secondary
area that you would most expect to find HPV related dysplasia
transformation zone of the cervix
the pink, shiny ectocervix is made of […] cells
squamous
the beefy red endocervix is made of […] cells
columnar
the squamous cells meet the columnar cells at the
squamo-columnar junction
area between the original SCJ and the new SCJ is called the
transformation zone
guidelines for CIN1 dysplasia
follow up in 1 year with HPV testing
(usually self resolves)
HPV associated anal SCC is 30x higher for what patient population?
PLWHIV
[…] immediate hypersensitivity is considered a contraindication for HPV vaccine
yeast
if pts receive the HPV vaccine under age 15, they receive […] doses
2
6-12 months apart
if pts receive the HPV vaccine over age 15, they receive […] doses
3
0, 1 month, and 6 months
strain of HPV that causes the majority of oropharygeal cancers
HPV 16
what area of the cervix is most prone to the development of HPV related cancer?
transformation zone
HPV subtypes 6, and 11 are most associated with
genital warts
most common side effects of the HPV vaccine
arm soreness
fainting
the 9-valent HPV vaccine protects against what strains?
6, 11, 16, 18, 31, 33, 45, 52, 58
viral oncogenes of HPV 18 [2]
E6 and E7
