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RDS Test 2 > B8-065 Assisted Reproductive Treatments > Flashcards

B8-065 Assisted Reproductive Treatments Flashcards

1
Q

if FSH is greater than […], recommend donor eggs or embryos

A

40

(probably WHO 3)

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2
Q

E2 is given to patients to thicken their endometrial lining, but can slow […] growth

A

follicular

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3
Q

E2 concentration peaks in the […] phase

A

late follicular

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4
Q

used as an LH analog
has a longer half life and less expensive

A

hCG

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5
Q

the oocyte is released about […] hours after onset of LH surge

A

34-36

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6
Q

following ovulation, the oocyte is arrested in what state of meiosis?

A

metaphase II

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7
Q

when does the placenta take over progesterone production?

A

8-10 weeks gestation

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8
Q

if a pregnant patient comes in with a ruptured luteal cyst and they are in early pregnancy, what needs to be given in order to maintain the pregnancy?

A

progesterone

(also in IVF, they give exogenous progesterone until 10 weeks because there is not corpus luteum)

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9
Q

why is the embryo transferred at day 6-7 in IVF?

A

that is when it would normally be in the uterus.

used to be transferred day 3-4, but physiologically the embryo would still be in the tube, a very different environment

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10
Q

fertilization occurs in the […]

A

ampulla

(why its a common location for ectopic)

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11
Q

inner cell mass of the blastocyst
becomes the

A

fetus

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12
Q

outer cell mass of the blastocyst becomes the

A

placenta/fetal membranes

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13
Q

IVF has a higher success rate with […] transfer due to stage matching

A

blastocyst

(vs. used to be day 3-4 cleavage stage; also lower twin rate)

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14
Q

blastocyst approaches uterine wall is called […]
blastocyst attaches to uterine wall is called […]

A

adplantation
adhesion

then, invasion/embedding

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15
Q

less than […] sperm is considered indication for ICSI

A

5 million

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16
Q

in Controlled Ovarian Hyperstimulation,
[…] antagonists are used daily to prevent ovulation
followed by […] agonist to trigger oocyte maturation

A

GnRH
hCG or GnRH

(retrieval is 34-36 hours after trigger)

17
Q

injection of sperm directly into mature oocyte (metaphase II)

A

ICSI

18
Q

most important predictory of IVF success at time of egg retrieval

A

advanced oocyte age (>35 years)

(more granular)

19
Q

most errors in meiosis resulting in aneuploid occur during what phase?

A

meiosis 1

(defects in spindle assembly)

20
Q

as oocyte age increases, rates of […] increase and rates of successful […] decrease

A

as oocyte age increases, rates of [aneuploidy] increase and rates of successful [implantation] decrease

21
Q

there is no evidence to support a […] cutoff for offering infertility treatment

A

BMI

22
Q

salpingitis due to untreated, asymptomatic […] is a primary cause of tubal infertility

A

chlamydia/gonorrhea

23
Q

if you have a communicating hydrosalpinx, […] is recommended before embryo transfer to prevent cytotoxic fluid reflux

A

salpingectomy

24
Q

direct testing of IVF embryo for single inherited disease

A

preimplantation genetic testing- monogenic (PGT-M)

(ex. CF)

25
Q

direct testing of IVF embryo for large scale chromosomal abnormalities

A

preimplantation genetic testing- aneuploidy (PGT-A)

(decreases chance of miscarriage and time to ART in women of AMA)

26
Q

insemination should be done between […] hours after oocyte retrieval for the best chance of fertilziation

A

3-5

27
Q

fully mature oocytes have [..]N number of chromosomes

A

1N

each with two chromatids

28
Q

when should oocyte retrieval be scheduled in relation to the hormonal injection give to mature oocytes?

A

34-36 hrs

29
Q

[…] is used to trigger oocyte maturation with an IVF cycle

A

hCG

30
Q

why is hCG used instead of LH to stimulate oocyte development?

A

less expensive
longer half life

31
Q

high levels of […] suppress ovulation

A

estradiol

32
Q

what is the order of event for standard fertilization

A

sperm preparation
sperm incubation for capacitation
activation of acrosomal digestion
cortical reaction

33
Q

prepared sperm for standard insemination are incubated in protein rich medium to achieve […]

A

capacitation

34
Q

the process by which spermatozoa become capable of going through the acrosomal reaction and fertilizing an oocyte

A

capacitation

35
Q

after sperm membrane fuses with the oocyte membrane, microvilli on the oocyte surround the sperm head and the oocyte releases […]

A

cortical granules

36
Q

the presence of hydrosalpinx with communication to the uterine cavity decreases rate of […] by about 50%

A

implantation

RDS Test 2 (21 decks)

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