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RDS Test 2 > B8-070 Drugs and Sexual Dysfunction > Flashcards

B8-070 Drugs and Sexual Dysfunction Flashcards

1
Q

how do antipsychotics affect female fertility?

A

D2 antagonists –> increase prolactin —> menstrual irregularity

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2
Q

how do estrogens/progestins cause anovulation?

A

impair LH/FSH surge

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3
Q

how do opioids affect female fertility?

A

decrease GnRH –> decrease LH –> menstrual irregularity

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4
Q

how do SSRIs affect female fertility?

A

decreased libido
anorgasmia

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5
Q

how do NSAIDs affect female fertility?

A

interfere with follicular rupture/ovulation

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6
Q

how do glucocorticoids affect female fertility?

A

interfere with LH, FSH

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7
Q

how do chemotherapy/radiation affect female fertility?

A

disrupt menstrual cycle due to
primary ovarian failure

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8
Q

how do anticonvulsants affect female fertility?

A

disrupt ovulation

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9
Q

how does spironolactone affect female fertility?

A

blocks 17a-hydroxylase –> decreased fertility

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10
Q

how do cannabinoids affect female fertility?

A

THC in the reproductive tract inhibits sperm mobility

may impact embryo transport/implantation

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11
Q

how does DES affect female fertility?

A

anomalies of the uterus/cervix
variable menstrual cycle

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12
Q

how does testosterone/anabolic steroids affect male fertility?

A

testicular atrophy
decreased sperm production

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13
Q

how do SSRIs affect male fertility?

A

ED
impaired ejaculation
sperm DNA fragmentation
decrease sperm motility

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14
Q

how does chemo/radiation affect male fertility?

A

decreased sperm production

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15
Q

how do Ca++ channel blockers affect male fertility?

A

decreased sperm motility
nefidipine blocks acrosome reaction

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16
Q

Ca++ channel blocker that affects the acrosome reaction

A

nefidipine

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17
Q

how do androgen antagonists affect male fertility?

A

decreased sperm production & semen volume

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18
Q

androgen antagonists are used to treat […] in men

A

prostate cancer

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19
Q

how does excess alcohol affect male fertility?

A

low T production, high T metabolism –> decreased sperm production

20
Q

how does tobacco affect male fertility?

A

decreased sperm production/motility

21
Q

how do cannabinoids affect male fertility?

A

decrease sperm production/function
low T production
low sex drive

22
Q

how do opiates affect male fertility?

A

lowers LH –> low T –> decreased sperm production

23
Q

how do 5a-reductase inhibitors affect male fertility?

A

lowers DHT –> low semen volume/number of sperm

24
Q

how do a-blockers affect male fertility?

A

antegrade anejaculation
lower semen volume
decrease sperm production/motility

25
a-blockers are used to treat [...] in men
BPH
26
how does ketoconazole affect male fertility?
inhibits 17a-hydroxylase --> decreased T --> decreased sperm production
27
how do anticonvulsants affect male fertility?
decrease sperm number/motility abnormal morphology decreased testicular volume
28
how do antiretrovirals affect male fertility?
decrease sperm number/motility abnormal morphology decreased ejaculate volume
29
how do antipsychotics affect male fertility?
ED D2 antaonists --> increase PRL
30
how does sulfasalazine affect male fertility?
antifolate and anti-PG activity causes decreased sperm number/motility
31
sulfasalazine is used to treat [...]
crohns, RA (anti inflammatory)
32
how does cimetidine affect male fertility? (H2 blocker)
decreased sperm number may have anti-androgenic effects
33
how does colchicine affect male fertility?
decrease sperm number
34
how do antibiotics affect male fertility?
decrease sperm number
35
how do anti-malarials affect male fertility?
decrease T production
36
how does cocaine affect male fertility?
decrease sperm number
37
how do estrogens affect male fertility?
decrease sperm number
38
how do heavy metals affect male fertility?
decrease sperm number, motility, lifespan Cr causes testicular atrophy
39
how does DES affect male fertility?
testicular hypoplasia decreased sperm number/motility abnormal morphology
40
alcohol greater than [...]drinks/week contributes to male infertility
14
41
NSAIDs can interfere with [...] in females
ovulation (interfere with follicular rupture) (no effect on male fertility)
42
MOA: cause feedback inhibition of GnRH from the hypothalamus
estrogens
43
negatively impact male fertility by causing ED, impaired ejaculation, and DNA fragmentation in sperm
SSRIs
44
can cause antegrade, anejaculation or decreased ejaculate volume
a-blockers (-zosins)
45
used to treat fungal infections and impairs steroidogenesis
ketoconazole

RDS Test 2 (21 decks)

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