B8-070 Drugs and Sexual Dysfunction Flashcards
how do antipsychotics affect female fertility?
D2 antagonists –> increase prolactin —> menstrual irregularity
how do estrogens/progestins cause anovulation?
impair LH/FSH surge
how do opioids affect female fertility?
decrease GnRH –> decrease LH –> menstrual irregularity
how do SSRIs affect female fertility?
decreased libido
anorgasmia
how do NSAIDs affect female fertility?
interfere with follicular rupture/ovulation
how do glucocorticoids affect female fertility?
interfere with LH, FSH
how do chemotherapy/radiation affect female fertility?
disrupt menstrual cycle due to
primary ovarian failure
how do anticonvulsants affect female fertility?
disrupt ovulation
how does spironolactone affect female fertility?
blocks 17a-hydroxylase –> decreased fertility
how do cannabinoids affect female fertility?
THC in the reproductive tract inhibits sperm mobility
may impact embryo transport/implantation
how does DES affect female fertility?
anomalies of the uterus/cervix
variable menstrual cycle
how does testosterone/anabolic steroids affect male fertility?
testicular atrophy
decreased sperm production
how do SSRIs affect male fertility?
ED
impaired ejaculation
sperm DNA fragmentation
decrease sperm motility
how does chemo/radiation affect male fertility?
decreased sperm production
how do Ca++ channel blockers affect male fertility?
decreased sperm motility
nefidipine blocks acrosome reaction
Ca++ channel blocker that affects the acrosome reaction
nefidipine
how do androgen antagonists affect male fertility?
decreased sperm production & semen volume
androgen antagonists are used to treat […] in men
prostate cancer