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RDS Test 2 > B8-020 Reproductive Pharmacology > Flashcards

B8-020 Reproductive Pharmacology Flashcards

1
Q

pulsatile release of GnRH […] release of LH and FSH

A

stimulates

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2
Q

sustained, non-pulsatile release of GnRH […] release of LH and FSH

A

inhibits

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3
Q

adverse effects of using GnRH to suppress gonadotropins

A

menopausal symptoms
osteoporosis

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4
Q

GnRH agonist

A

gonadorelin

(half life 4 min as opposed to analogs with half life of 3 hours)

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5
Q

GnRH analogs [3]

A

leuprolide
goserelin
nafarelin

(half life 3 hrs intranasal)

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6
Q

GnRH antagonist

A

ganirelix

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7
Q

class used to stimulate ovulation induction and treat male infertility

A

gonadotropins

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8
Q

major risk of using gonadotropins to stimulate ovulation

A

ovarian hyperstimulation syndrome –> multiple pregnancies

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9
Q

FSH agonists [2]

A

urofollitropin
follitropin

(from urine of post menopausal women)

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10
Q

LH agonist

A

lutropin alfa

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11
Q

menotropin [1]

A

human menopausal gonadotropin (hMG)

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12
Q

hCG is most similar to [LH/FSH]

A

LH

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13
Q

[hCG/hMG] stimulates both LH and FSH equally

A

hMG

(hMG is more $$$)

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14
Q

estrogen binds to receptors and initiates gene transcription by binding to […]

A

ERE

estrogen response element

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15
Q

adverse effects of estrogens [2]

A

accelerated blood clotting
endometrial proliferation (unopposed)

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16
Q

which type of estrogen is the major product of the ovary?

A

estradiol E2

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17
Q

metabolically resistant pro-hormone version of estrogen

improves bioavailability

A

estrogen esters

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18
Q

equine estrogen sulfate sodium blended into standardized activity

A

conjugate estrogens

(very high potency)

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19
Q

estropipate is a [natural/synthetic] estrogen

A

natural

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20
Q

estrogen esters are a [natural/synthetic] estrogen

A

natural

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21
Q

conjugated estrogens are a [natural/synthetic] estrogen

A

natural

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22
Q

ethinyl estrogen is a [natural/synthetic] estrogen

A

synthetic

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23
Q

diethylstilbestrol (DES) is a [natural/synthetic] estrogen

A

synthetic

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24
Q

esterified estrogens are a [natural/synthetic] estrogen

A

synthetic

(manufactured from soybeans/yams)

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25
estrogen that is implicated in clear cell carcinoma of the vagina in exposed female offspring
DES diethylstilbestrol
26
progesterone itself must be administered [...]
IM poor oral bioavailability
27
androgenic progestins that may decrease plasma HDL [3]
medroxyprogesterone acetate norethindrone levonorgestrel
28
which progestin agonist is closest to pure progesterone [2]
desogestrol drospirenone
29
major adverse effect of hormone contraceptives
venous thromboembolism
30
most hormonal contraceptives contain what type of estrogen?
ethinyl estradiol
31
suppress the FSH/LH surge
hormonal contraception
32
unopposed estrogen in postmenopausal women who still have a uterus can lead to [...]
uterine cancer
33
E+P in postmenopausal women can increase the risk of [...] cancer
breast
34
oral SERM used for ovulation induction
clomiphene
35
SERM used to treat breast cancer
tamoxifen
36
tamoxifen is an antagonist at the [...] and partial agonist at [...]
tamoxifen is an antagonist at the [breast] and partial agonist at [uterus and bone]
37
raloxifene is an antagonist at the [...] and agonist at [...]
raloxifene is an antagonist at the [uterus and breast] and agonist at [bone]
38
SERM used to treat osteoporosis
raloxifene
39
partial agonist at ERa and antagonist at ERb
clomiphene
40
oral SPRM used for emergency contraception and fibroids
ulipristal acetate
41
estrogen antagonist used to treat tamoxifen resistant breast cancer
fulvestrant
42
progesterone antagonist used as abortifacient with misoprotrol
mifepristone (can be used as postcoital contraceptive)
43
aromatase inhibitors [3]
anastrazole letrozole exemestane
44
steroidal irreversible aromatase inhibitor
exemestane
45
class used for breast cancer in post-menopausal women to block estrogen production by peripheral tissues
aromatase inhibitors
46
androgens bind to intracellular receptors and lead to gene expression via [...]
ARE androgen response element
47
adverse effects of androgens [4]
acne gynecomastia testicular atrophy/azoospermia masculinization
48
testosterone esters are administered via
IM oily depot
49
testosterone is most commonly administered via
transdermal patch, gel (careful not to get it on partners/kids)
50
oral androgens [3]
methyltestosterone fluoxymetstrone oxandrolone
51
androgen receptor inhibitors are primarily used for
prostate cancer
52
androgen receptor inhibitors [3]
cyproterone flutamide spironolactone
53
steroid synthesis inhibitors [4]
ketoconazole abiraterone finasteride dutasteride
54
leuprolide is a [...] agonist
GnRH
55
flutamide is a [...] antagonist
androgen receptor
56
MOA of finesteride
5a-reductase inhibitor
57
fluoxymestrone is a [...] agonist
androgen
58
testosterone derivative with weak progestin, androgen, and glucocorticoid activity
danazol
59
estrogen antagonist used in tamoxifen-resistant breast cancer
fulvestrant
60
unopposed estrogens may be used in what patient population?
those who have undergone hysterectomy
61
can be used to induce ovulation has greater LH activity than FSH activity
hCG
62
can be used to induce ovulation has equal LH activity and FSH activity
hMG
63
used to induce ovulation by blocking negative feedback by estrogen at the pituitary, resulting in increased LH and FSH
SERMs
64
low-efficacy progesterone partial agonist used as abortifacient in combination with a prostaglandin
mifepristone
65
most widely used estrogen in oral contraceptives in combination with progestin
ethinyl estradiol

RDS Test 2 (21 decks)

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