B.7 - Plant with complex effects, oxalate and nitrate poisoning (mechanism of action, effects, symptoms)

Question 1

How does Thujone affect the body?

Answer 1

1. Bind to to GABA receptors
2. Opening Cl^- channels in neurons
3. Hyperpolarisation of cell membranes

Question 2

What are the Symptoms of Thujone poisoning?

Answer 2

• Dermatitis
• Seizures
• Liver Damage
• Kidney Damage

Question 3

How does Ranunculin affect the body?

Answer 3

1. Ranunculin is cleaved to form protoanemonin
2. Reacts with DNA & RNA polymerases
3. Cell Death, Inhibited cell mitosis, Growth Depression

Question 4

What are the symptoms of Ranunculin?

Answer 4

• Tarry Diarrhoea
• Bitter Milk
• Seisures
• Stumbling walk

Question 5

How to Oxalates affect the body?

Answer 5

1. Oxalate crystals penetrate the skin and mucous membranes
2. Oxalosis (Inflammation, salivation

Question 6

How do nitrate ions affect the body?

Answer 6

1. Bacteria reduce Nitrate → Nitrite ions
2. Ions can oxidise the Iron(II) in haemoglobin to Iron (III)
3. Methemoglobinemia

Question 7

Why are Ruminants susceptible to Nitrate ions?

Answer 7

• High population of bacteria
• More Nitrate ions are reduced to Nitrite

Question 8

What are the symptoms of Nitrate ions?

Answer 8

• Blue Skin
• Headache
• Tachpnea
• Palpatations