B4W1 Trans Flashcards
Diagnoses of Diabetes
Fasting Blood Glucose of >126 mg/dl
Random Glucose of >200 mg/dl
Type 1 Diabetes
loss of insulin production
Type 2 Diabetes
Initial insulin resistance
B-Cell failure and decreased insulin secretion
Thrifty Gene Hypothesis
Proposal that genes that lead to diabetes were helpful in situations in which food was scarce
Risk Factors for Diabetic Kidney Disease
Race/Genetics, Gender, Obesity, Poor Glycemic Control, Hypertension and diabetic complications
Trend of Type 1 Diabetes GFR and Albumin Excretion
Around 16 years after onset Albumin excretion increases and GFR decreases
Diagnoses of Diabetic Kidney Disease
Low GFR <60 ml/min
Albuminuria or Albumin in Urine >30 mg albumin or 300 mg protein per 24 hours of urine collected
Streptozotocin Medication
Medication initially proposed as an antibiotic but was found to be toxic to B-Cells and cause diabetes in animals
Role of Leptin
Leptin is found within adipose tissue and inhibits insulin release and suppresses appetite
Intraglomerular Hypertension and Hyperfiltration
Hypertension leads to an increase in blood flow within the glomerulus
Endothelin Effect on Na reabsorbtion