Assisted conception Flashcards
Advice prior to commencing ACT (6)
Alcohol- fewer than 4 units per week BMI 19-29 Stop smoking Folic acid 0.4mg/day Rubella check +/- immunization Cervical smears up to date
Main indications for intra-uterine insemination (3)
Male factor
Endometriosis
Unexplained
What does Buserelin do and when should it be commenced?
Causes down-regulation of GnRH receptors, thereby reducing FSH/LH release. Day 21 of the cycle
When should the baseline scan for IVF be undertaken?
2-3 weeks after commencing Buserelin nasal spray
After the baseline scan, how is ovarian stimulation achieved?
Daily injections of FSH
When should the action scan be taken?
8 or 9 days after FSH is commenced
What does hCG achieve in IVF?
Mimics the LH spike
When are eggs collected?
About 36 hours after hCG
How many embroys should be transferred?
Under age 40-maximum 2
Over age 40- maximum 3
How is the luteal phase mimicked in IVF?
Cyclogest (progesterone) pessary for two weeks after embryo transfer
What features of the partner/donor sperm are assessed? (4)
Volume, density, motility, progression
What are the indications for intracytoplasmic sperm injection?
Male factor (severe) Previous failed IVF
How might azoospermia be managed in the context of IVF/ICSU?
Surgical sperm aspiration
How does the method for ICSU differ from IVF?
The egg is stripped, the sperm are immobilised and one single sperm is injected
What is the underlying cause of ovarian hyperstimulation syndrome?
Excess stimulation -> excess follicles and enlarged ovaries. Release of vasoactive substances