Antivirals

Question 1

obligate parasite
must find a host to live and multiply

Answer 1

Virus

Question 2

substance that stimulates the production of antibodies and provide immunity against viral diseases

Answer 2

Vaccine

Question 3

Antiviral meds

Answer 3

Influenza - amantadine, oseltamivir, zanamivir

Hepatitis - adefovir

Herpes - acyclovir, valaciclovir

HIV - zidovudine, lamivudine

Question 4

Herpes simplex infections

Answer 4

Chicken pox/ shingles, cold sores and genital herpes

Question 5

Pharmacodynamics of Acyclovir and Valaciclovir

Answer 5

Acyclovir is metabolised to active aciclovir triphosphate
- inhibits viral enzyme
- blocks viral replication
- acting as a false substrate in DNA synthesis

Valaciclovir - pro-drug of Acyclovir
- first pass thru liver converted to acyclovir

Question 6

Adverse effects of Aciclovir & Valaciclovir

Answer 6

Cotard’s syndrome - rare psychiatric condition causing strong delusions of being DEAD

Neuropsychiatric S&S of aciclovir:
- confusion
- somnolence (drowsiness)
- hallucinations
- associated with renal impairment

Question 7

Pre-exposure prophylaxis (PrEP) contains two antiviral meds:

Answer 7

tenofovir and emtricitabine