Antifungals

Question 1

More complex than bacteria - opportunistic and can cause immune weakness

Answer 1

Fungi

Question 2

Fungal infections eg.

Answer 2

ringworm
athlete’s foot
nail infections
thrush
systemic infections

Question 3

Antifungal meds

Answer 3

Topical:
miconazole
ketoconazole
clotrimazole

PO:
nystatin
fluconazole
itraconzole

Question 4

Pharmacodynamics of Nystatin (oral drops)

Answer 4

interfere with synthesis of sterols in the cell membrane leading to structural and functional impairment of fungal cytomembrane
inhibits cell growth

Question 5

Pharmacodynamics of miconazole

Answer 5

interfere with sterol synthesis in the cell membrane impairing structural and functional process of fungal cytoplasmic membrane
inhibits cell growth

Topical use: apply 2x daily

Question 6

Pharmacodynamics of fluconazole

Answer 6

interfere with sterol synthesis in the cell membrane impairing structural and functional process of fungal cytoplasmic membrane
CP450 dependant

Cautions:
Pregnancy: multiple congenital abnormalities reported from long-term high doses
Hepatoxic
Increases QT interval

Take after food