Antipsychotic Meds Flashcards

1
Q

list the neurotransmitter most tied to antipsychotic efficacy and motor side effects

A

dopamine

all antipsychotics block D2 receptors

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2
Q

state differences in adverse affects between low potency (chlorpromazine) and high potency 1st gens (haloperidol)

A

Chlorpromazine: more weight gain, more sedation

Haloperidol: more prolactin, more extrapyramidal side effects

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3
Q

state unique clinical profiles (efficacy and EPS risk) and major adverse effects for clozapine

A

efficacy: efficacious! only drug with proven therapeutic superiority, some efficacy against neg symptoms

extrapyramidal symptoms risk: does not cause EPS at all!

adverse side effects: risk of agranulocytosis, seizures! drug interactions

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4
Q

describe extrapyramidal adverse effects of antipsychotic meds, and which are most/least likely to cause them

A

EPS: parkinsonism, dystonia, akathisia

MOST likely to be caused by “-done/-ole” drugs (risperidone, haloperidol)

LEAST likely to be caused by “-pine” drugs (clozapine, quetiapine)

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5
Q

how to medically manage adverse effects of antipsychotic meds

A

treat dystonia with anticholinergics

treat (bilateral) parkinsonism by switching drug to benztropine!

treat akathisia (restless leg syndrome) with propranolol

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6
Q

describe how antipsychotics affect prolactin

A

blockade of tuberoinfundibular dopamine receptors can increase prolactin, cause gynecomastia, and galactorrhea

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7
Q

drug list

A
chlorpromazine
haloperidol
clozapine
risperidone
olanzapine
quetiapine
ziprasidone
aripiprazole
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