Antiphospholipid Syndrome Flashcards
1
Q
What is APS?
A
a disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss
2
Q
What are the signs of ASP?
A
increased anticardiolipin
recurrent pregnancy loss
thrombocytopenia - low levels of platelets in blood
levido reticularis - blotchy nodules on skin
3
Q
What are the investigations for ASP?
A
CXR, ECHO, blood tests
- presence of ASP antibodies on 2 occasions, 12 weeks apart
4
Q
What is the pathophysiology of ASP?
A
an autoimmune condition where antibodies are produced against phospholipid causing an increased risk of blood clots
5
Q
What is the treatment of ASP?
A
lifelong anticoagulation
6
Q
What is the treatment of ASP while pregnant?
A
LMWH and aspirin
7
Q
What is secondary ASP?
A
seen in 20% of patients with lupus
