Ankylosing Sponylitis Flashcards
1
Q
What is AS?
A
chronic inflammatory disorder that primarily affects the spine
2
Q
What is the hallmark of AS?
A
sacroilliac joint involvement
3
Q
What is the peak age of AS? Male or female?
A
late adolesence and early adulthood (20-40)
male x3
4
Q
What are the signs of AS?
A
back pain enthesitis anterior uveitis amyloidosis aortic valve problems pulmonary fibrosis enteric mucosal inflammation neurological involvement peripheral arthritis loss of lumbar lordosis and increased thoracic kyphosis
5
Q
What does AS look like on Xray?
A
all of the vertebrae are fused together
- hunched back
6
Q
What is the investigations for AS?
A
X ray - sacroilitis and syndemophytes (decreased bone density)
Schobers test
Bloods - HLA-B27 and inflammatory markers
MRI - shows early changes
7
Q
What is the non pharmacological treatment for AS?
A
physiotherapy
occupational therapy
8
Q
What is the pharmacological treatment for AS?
A
NSAIDs
Anti TNF - infliximab etc..
Secukinumab anti IL-17
DMARDs if peripheral arthritis
