Antimicrobial drugs Flashcards
Antimicrobial drugs are classified on the basis of
- Molecular structure
- Mechanism of action
- Spectrum of antimicrobial activity
Can be used internally in humans or animals with minimal side effects (low toxicity) but for the organism?
toxicity really high
antimicrobial drugs can be ?
bacteriostatic or bactericidal
usually the antimicrobial drgs have target? s
specific targets
A good antimicrobial drug has
- No severe side effect
- low risk-benefit ratio
- Broad spectrum of activity to facilitate rapid medical intervention
- low cost to develop and manufacture
- Appropriate bioavailability and pharmacokinetics (must reach the site of infection).
Antimicrobial drugs ‐ Mode of action can target ?
specific subunits, lipid biosynthesis,
can a drug threat at the same time bacteria and virus?
nop
Who studied selective toxicity in the early 1900s?
Paul Ehrlich
Selective toxicity is the?
ability
to inhibit or kill a pathogen
without affecting the host
Salvarsan?
one of the first
antimicrobial drugs, used to
treat syphilis
What’s a synthetic Antimicrobial drug?
drug that are not naturally produce cooked up in the lab
Synthetic Antimicrobial Drugs,growth factor analogs?
structurally similar to growth
factors but do not function in the
cell.
so what do growth facto analogs do?
prevent the analog from functioning in the cell, thereby disrupting cell metabolism
Who discovered the sulfa drug?
discovered by Gerhard Domagk
Another name for sulfa drug?
sulfanilamide
