Antimicrobial Drug Resistance Flashcards
Antimicrobial drug resistance
The acquired ability of a microorganism to resist the effects of a
chemotherapeutic agent to which it is normally sensitive
Antibiotic producers are tolerant,what does that mean?
- lacK target site
- Modify target sites
- Lack of uptake mechanism
Some microorganisms are
_____ to some antibiotics.
resistant
Antibiotic resistance mechanism?
-Destruction or modification of the antibiotic -Modification of the target site -Modification of uptake mechanism -Efflux pumps: reduce intracellular concentration
Antimicrobial Drug Resistance,can be minimized by using
antibiotics correctly and only when
needed?
called reduce selection
Acquisition of resistance, is usually mediated by?
the acquisition of a new gene (or groups of genes) that provide the cells with a new function (
where are located most drug-resistant bacteria ?
located on R plasmids.
R plasmids can be transferred
between
bacteria of the same species or related
species.
The use of antibiotics in medicine,
veterinary medicine, and agriculture selects
for the spread of R plasmids.
Evidence indicates that R plasmids predate
the antibiotic era (antibiotics come from
nature). meaning?
the appeared before viennt de la nature
Most antiviral drugs also target host structures,resulsting in?
toxicity
if the host is affected?
Risk to the host may not justify the use of
antiviral.
Most successful and commonly used antivirals are the
nucleoside analogs:block reverse transcriptase and production of viral
DNA (RNA viruses).
Protease inhibitors
inhibit the processing of large viral proteins into
individual components.
Fusion inhibitors
prevent viruses from successfully fusing with the host
cell.
