Animal viruses Flashcards
in eukaryotic cells where does DNA replication occurs??
in the nucleus
the genome of DNA viruses is usually replicated in ?
the nucleus of the cell
the genome of RNA viruses will usually be replicated in ?
the cytoplasm of the cell
how is the penetration in a eukaryotic cell?
Quand c dedans where is transported the nucleocapsid?
transported to the nucleus where viral DNA is uncoated
host transcription-translation apparatus synthesizes?
- imediate early proteins
- Delayed early proteins
- late protein
what are the imediate early protein ?
- transcription factors
- virus-specific DNA polymerase
what are the delayed early proteins?
-viral-specific DNA
polymerase
-other proteins necessary of replication
what are the late proteins?
nucleocapsid
Where occurs the assembly?
in the nucleus,
How is added the envelope?
is added via budding process through the inner membrane
By what are the virions secreted out of the cell ?
the ER-Golgi pathway
if we have ssDNA genome?
first converted to dsDNA replicative form
RNa genome, plus strand RNA example?
Poliovirus, Hepatitis A virus
the RNA,plus strand RNA can be ? t
translated directly
in poliovirus , the plus-strand RNA serves as?
template(matrice) for synthesis of a large polyprotein that is cleaved into proteins
How is transmitted polio?
usually through faecal-oral route
does it have symptomes polio?
little to no symptoms in 99% of cases
paralytic polio in 0.5-1% of cases
What does polio causes ?
Skeletal deformities post-paralytic polio
Does polio have a cure ?
No cure,but safe and effective vaccine
minus-strand RNA example?
Measles,Rabies,(rhabdovirus)
what happens because its a minus-strand RNA?
genome cannot be translated directly
The RNA genome minus strans is first?
transcribed into a plus-strand RNA by an RNA dependent RNA polymerase carried inside the virion
when was eradicated measles?
in 2000
