Animal viruses

Question 1

in eukaryotic cells where does DNA replication occurs??

Answer 1

in the nucleus

Question 2

the genome of DNA viruses is usually replicated in ?

Answer 2

the nucleus of the cell

Question 3

the genome of RNA viruses will usually be replicated in ?

Answer 3

the cytoplasm of the cell

Question 4

how is the penetration in a eukaryotic cell?

Question 5

Quand c dedans where is transported the nucleocapsid?

Answer 5

transported to the nucleus where viral DNA is uncoated

Question 6

host transcription-translation apparatus synthesizes?

Answer 6

• imediate early proteins
• Delayed early proteins
• late protein

Question 7

what are the imediate early protein ?

Answer 7

• transcription factors

- virus-specific DNA polymerase

Question 8

what are the delayed early proteins?

Answer 8

-viral-specific DNA
polymerase
-other proteins necessary of replication

Question 9

what are the late proteins?

Answer 9

nucleocapsid

Question 10

Where occurs the assembly?

Answer 10

in the nucleus,

Question 11

How is added the envelope?

Answer 11

is added via budding process through the inner membrane

Question 12

By what are the virions secreted out of the cell ?

Answer 12

the ER-Golgi pathway

Question 13

if we have ssDNA genome?

Answer 13

first converted to dsDNA replicative form

Question 14

RNa genome, plus strand RNA example?

Answer 14

Poliovirus, Hepatitis A virus

Question 15

the RNA,plus strand RNA can be ? t

Answer 15

translated directly

Question 16

in poliovirus , the plus-strand RNA serves as?

Answer 16

template(matrice) for synthesis of a large polyprotein that is cleaved into proteins

Question 17

How is transmitted polio?

Answer 17

usually through faecal-oral route

Question 18

does it have symptomes polio?

Answer 18

little to no symptoms in 99% of cases

paralytic polio in 0.5-1% of cases

Question 19

What does polio causes ?

Answer 19

Skeletal deformities post-paralytic polio

Question 20

Does polio have a cure ?

Answer 20

No cure,but safe and effective vaccine

Question 21

minus-strand RNA example?

Answer 21

Measles,Rabies,(rhabdovirus)

Question 22

what happens because its a minus-strand RNA?

Answer 22

genome cannot be translated directly

Question 23

The RNA genome minus strans is first?

Answer 23

transcribed into a plus-strand RNA by an RNA dependent RNA polymerase carried inside the virion

Question 24

when was eradicated measles?

Answer 24

in 2000

Question 25

why are they new cases?

Answer 25

lack of vaccination

Question 26

contre measles ?

Answer 26

safe and effective vaccine

Question 27

can dsRNA be translated directly?

Answer 27

no it can’t

Question 28

how can we translate a dsRNA ?

Answer 28

a + strand RNA must be synthetized by a viral encoded RNA-dependent RNA polymerase using the minus strand as the template

Question 29

what happen with the + strand that was synthetized for dsRNA?

Answer 29

is translated into proteins and is used as a template to synthesize a minus strand to yield dsRNA genomes

Question 30

retrovirus cause?

Answer 30

HIV ,cancer (Rous sarcoma virus)

Question 31

the retrvirus carries ?

Answer 31

two identical copies of the genome (+-strand ssRNA) ,reverse transcriptase,integrase and proteases

Question 32

What’s the reverse transcriptase?

Answer 32

an RNA-dependent DNA polymerase that reverse transcribes the RNA genome into DNA genome

Question 33

the DNA genome travels where?

Answer 33

to the nucleus and is integrated into the host DNA

Question 34

how does it do the integration into the host DNA?

Answer 34

LTR:long terminal repeats.Contain promotes for transcription and participate in the integration process

Question 35

provirus is a kind of retrovirus?

Answer 35

integrates into the viral DNA

Question 36

provirus contrary to lamda?

Answer 36

cannot excise from the host genome